Diagnostic yield of endoscopy in irritable bowel syndrome: A nationwide prevalence study 1987-2016

We examined the yield of colonoscopy and upper endoscopy in IBS for several organic diseases.METHODS: Matched population-based prevalence study in Sweden. We identified 21,944 participants diagnosed with IBS from 1987 to 2016 undergoing colonoscopy with a biopsy from all of Sweden's 28 pathology departments within 6 months of diagnosis. We compared prevalence of histopathology-proven diagnoses of inflammatory bowel disease (IBD), colorectal cancer, precancerous polyps, and microscopic colitis between patients recently diagnosed with IBS and matched controls without IBS (n = 81,101) undergoing colonoscopy. We also compared prevalence of celiac disease between patients diagnosed with IBS (n = 9,965) and matched controls (n = 45,584) undergoing upper endoscopy with biopsy. IBS patients were also compared to their siblings. Conditioned logistic regression estimated adjusted odds ratios (aORs).RESULTS: Biopsy-proven IBD was seen in 1.6% of IBS and in 5.9% of controls (aOR=0.21; 95%CI=0.19-0.24). The prevalence of precancerous polyps was 4.1% vs. 13.0% (aOR=0.28; 95%CI=0.26-0.30), colorectal cancer 0.8% vs. 6.3% (aOR=0.17; 95%CI=0.14-0.20) and celiac disease 1.9% vs. 3.4% (aOR=0.54; 95%CI=0.47-0.63). Conversely, the prevalence of microscopic colitis was 2.9% vs. 1.7% (aOR=1.77; 95%CI=1.61-1.95), with higher prevalence in older patients and patients with IBS with diarrhea. Yield of colonoscopy for precancerous polyps, colorectal cancer, and microscopic colitis increased by age. Our ...
Source: European Journal of Internal Medicine - Category: Internal Medicine Authors: Source Type: research

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AbstractAccurate staging and re-staging of cancer in children is crucial for patient management. Currently, children with a newly diagnosed cancer must undergo a series of imaging tests, which are stressful, time-consuming, partially redundant, expensive, and can require repetitive anesthesia. New approaches for pediatric cancer staging can evaluate the primary tumor and metastases in a single session. However, traditional one-stop imaging tests, such as CT and positron emission tomography (PET)/CT, are associated with considerable radiation exposure. This is particularly concerning for children because they are more sensi...
Source: Pediatric Radiology - Category: Radiology Source Type: research
big dreamer here: if you were starting out as a first year med student, what is the path you’d take to secure a dream job specializing in lung cancer and related environmental research/advocacy at an academic medical center? what about while adding on an MBA and wanting to combine academia with entrepreneurship to find better lung cancer therapies?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Medical Students (MD) Source Type: forums
ConclusionsOur study confirms and extends our knowledge on the tyrosine kinase inhibitors effects on thyroid, showing that thyroid autoimmunity is frequently observed in chronic myeloid leukemia patients on long-term therapy and is associated with a better oncological response.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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Source: International Journal of General Medicine - Category: General Medicine Tags: International Journal of General Medicine Source Type: research
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Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Am J Pathol. 2022 Jan 18:S0002-9440(22)00006-2. doi: 10.1016/j.ajpath.2021.12.006. Online ahead of print.ABSTRACTAlthough Glycolysis plays a pivotal role in breast cancer stem-like cells (BCSCs) reprogramming, the molecular mechanisms that couple glycolysis to cancer stem-like cell remain unclear. The SET-domain containing 5 (SETD5) is a previously uncharacterized member of the histone lysine methyltransferase family. The goal of this study was to explore the mechanisms underlying the promotion of stem-like and glycolysis activation traits by SETD5. Previous study displayed that overexpression of SETD5 in breast cancer (BC...
Source: The American Journal of Pathology - Category: Pathology Authors: Source Type: research
In this study, we employed an integrative analysis framework of functional genomics approaches and machine learning methods to the lncRNA, miRNA, and mRNA data and identified 16 RNAs (3 lncRNAs, 6 miRNAs, and 7 mRNAs) of prognostic value with 9 of them novel. We then established a 16-RNA-based score for prognosis prediction of ccRCC with significance (p-value
Source: The American Journal of Pathology - Category: Pathology Authors: Source Type: research
Am J Pathol. 2022 Jan 18:S0002-9440(22)00006-2. doi: 10.1016/j.ajpath.2021.12.006. Online ahead of print.ABSTRACTAlthough Glycolysis plays a pivotal role in breast cancer stem-like cells (BCSCs) reprogramming, the molecular mechanisms that couple glycolysis to cancer stem-like cell remain unclear. The SET-domain containing 5 (SETD5) is a previously uncharacterized member of the histone lysine methyltransferase family. The goal of this study was to explore the mechanisms underlying the promotion of stem-like and glycolysis activation traits by SETD5. Previous study displayed that overexpression of SETD5 in breast cancer (BC...
Source: Am J Pathol - Category: Pathology Authors: Source Type: research
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