Effect of Three NR3C1 mutations in Pathogenesis of Pituitary ACTH Adenoma

CONCLUSION: Our findings identify 3/49 (6.1%) consecutive human corticotroph tumors harboring GR mutations. Further findings demonstrate the role NR3C1 plays in CD pathogenesis and offer insights into a novel treatment approach in this patient subset.PMID:34427636 | DOI:10.1210/endocr/bqab167

Source: Endocrinology - August 24, 2021 Category: Endocrinology Authors: Hui Miao Yang Liu Lin Lu Fengying Gong Linjie Wang Lian Duan Yong Yao Renzhi Wang Shi Chen Xinxin Mao Dongyun Zhang Anthony P Heaney Huijuan Zhu Source Type: research