Predictive modeling of hypophosphatasia based on a case series of adult patients with persistent hypophosphatasemia

ConclusionsGiven the high probability of a misdiagnosis, its nonspecific symptoms, and a lack of awareness of serum ALP levels, it is difficult to make a clinical diagnosis of HPP. Predictive models based on biomarkers are necessary to achieve a proper diagnosis. Our proposed machine learning approaches achieved reasonable performance compared to traditional statistical methods used in biomedicine, increasing the likelihood of properly diagnosing such a rare disease as HPP.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research