Emerging therapeutic targets for narcolepsy
ConclusionsOur codebook of anti-vaccine topics can help public health professionals better understand social media content. Real-time monitoring of social media is important because the popularity of certain arguments on Facebook changes rapidly over time but early recognition of social doubts allows for targeted interventions.Key messagesOnline anti-vaccine comments on the COVID-19 vaccines can be divided into 12 topic categories.The frequency of Facebook comments against COVID-19 vaccines from a given topic category varies over time.
CONCLUSION: The target engagement of enerisant was demonstrated in the brains of living human subjects. The occupancy of histamine H3 receptors by enerisant at 2 h can be predicted by applying the plasma concentration of enerisant to Hill's plot. The preliminary time-course investigation showed persistently high brain occupancy with high doses of enerisant despite the decreasing plasma concentration of the drug. Five milligrams or less dose would be appropriate for the treatment for narcolepsy with initially high occupancy allowing for effective treatment of narcolepsy, and then the occupancy level would be expected to dec...
This session aims to discern the differences in demographic, comorbidities, and hospital outcomes associated with narcolepsy in adolescents hospitalized for mood disorders.
The objectives of this presentation are as follows: 1) the attendee will describe the differential diagnosis for a youth presenting with excessive daytime sleepiness; 2) the attendee will recognize risk factors for obstructive sleep apnea (OSA) in youth and formulate a treatment plan; and 3) the attendee will outline the assessment of youth at risk for narcolepsy.
Radiol Technol. 2021 Sep;93(1):106-109.NO ABSTRACTPMID:34588284