M1 macrophage-derived exosomes impair beta cell insulin secretion via miR-212-5p by targeting SIRT2 and inhibiting Akt/GSK-3 β/β-catenin pathway in mice

Conclusions/interpretationA novel exosome-modulated mechanism was delineated for macrophage-beta cell crosstalk that drove beta cell dysfunction and should be explored for its therapeutic utility.Graphical abstract
Source: Diabetologia - Category: Endocrinology Source Type: research