Branched-chain amino acid metabolism is regulated by ERR α in primary human myotubes and is further impaired by glucose loading in type 2 diabetes

Conclusions/interpretationMetabolic inflexibility in type 2 diabetes impacts BCAA homeostasis and attenuates the decrease in circulating and skeletal muscle BCAA-related metabolites after a glucose challenge. Transcriptional regulation of BCAA genes in primary human myotubes via PGC-1 α is ERRα-dependent.Graphical abstract

http://link.springer.com/10.1007/s00125-021-05481-9

Source: Diabetologia - August 24, 2021 Category: Endocrinology Source Type: research