B lymphocytes accumulate and proliferate in human skin at sites of cutaneous antigen challenge

To the Editor, B cells play important roles in skin diseases (Egbuniwe et al., 2015) and in cutaneous homeostasis (Geherin et al., 2012, Geherin et al., 2016, Nihal et al., 2000). Mature class-switched IgG+ B cells have been detected in normal human skin (Saul et al., 2016) featuring clonally-restricted B cell receptors, indicating narrow antigenic repertoires (Nihal et al., 2000). However, the involvement of B cells during an antigenic stimulus in human skin remains unexplored. B cells are relatively scarce in normal human skin (Supplementary Figure 1), explaining why past studies have primarily focused on T cells which constitute the major skin-resident lymphocyte population (Clark et al., 2006b, Jiang et al., 2012, Sanchez Rodriguez et al., 2014).

Source: Journal of Investigative Dermatology - August 24, 2021 Category: Dermatology Authors: Isioma U. Egbuniwe, Robert J. Harris, Mano Nakamura, Frank O. Nestle, Arne N. Akbar, Sophia N. Karagiannis, Katie E. Lacy Tags: Letters to the Editor Source Type: research