HLA class I genes modulate disease risk and age at onset together with DR-DQ in Chinese patients with insulin-requiring type 1 diabetes

Conclusions/interpretationIn addition toDR-DQ haplotypes, novel HLA class I alleles were detected to play a role in susceptibility to type 1 diabetes with different onset ages, which could improve the understanding of disease heterogeneity and has implications for the design of future studies.Graphical abstract

http://rd.springer.com/10.1007/s00125-021-05476-6

Source: Diabetologia - August 24, 2021 Category: Endocrinology Source Type: research