Antihypertensive medication needs and blood pressure control with weight loss in the Diabetes Remission Clinical Trial (DiRECT)

Conclusions/interpretationReplacing antihypertensive medications with a 3470  kJ/day (830 kcal) diet to induce weight loss reduces BP substantially and may increase mild dizziness. It is safe to stop antihypertensives, but BP should be monitored regularly, particularly for those taking two or more antihypertensives, as over two-thirds will require reintroduction of some me dications. Long-term support to maintain weight loss is vital.Trial registrationISRCTN registry, number 03267836.Graphical abstract
Source: Diabetologia - Category: Endocrinology Source Type: research