Pitolisant, a wake ‐promoting agent devoid of psychostimulant properties: Preclinical comparison with amphetamine, modafinil, and solriamfetol

In conclusion, pitolisant is a differentiated therapeutic option, when compared with psychostimulants, for the treatment of EDS, as this agent does not show any amphetamine-like properties within in vivo preclinical models.
Source: Pharmacology Research and Perspectives - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL ARTICLE Source Type: research

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The objectives of this presentation are as follows: 1) the attendee will describe the differential diagnosis for a youth presenting with excessive daytime sleepiness; 2) the attendee will recognize risk factors for obstructive sleep apnea (OSA) in youth and formulate a treatment plan; and 3) the attendee will outline the assessment of youth at risk for narcolepsy.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: Clinical Perspectives 27 Source Type: research
In conclusion, across three large clinical trials of participants with narcolepsy or obstructive sleep apnea, Epworth Sleepiness Scale scores demonstrated a robust acceptable level of test-retest reliability in evaluating treatment response over time.PMID:34545626 | DOI:10.1111/jsr.13476
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Source Type: research
Epilepsy Behav. 2021 Sep 14;124:108311. doi: 10.1016/j.yebeh.2021.108311. Online ahead of print.ABSTRACTExcessive daytime sleepiness (EDS) and attentional deficits are often observed in people with epilepsy. They may be the consequence of seizures and subclinical discharges as well as of comorbid conditions as obstructive sleep apnea/hypopnea syndrome (OSAS), attention deficit hyperactivity disorder (ADHD), or other less frequent disorders. Excessive daytime sleepiness may also be caused or worsened by antiseizure medications (ASMs). Several meta-analyses suggested that lamotrigine, lacosamide, and perhaps eslicarbazepine ...
Source: Epilepsy and Behaviour - Category: Neurology Authors: Source Type: research
ConclusionsMinimally important difference and clinically important response estimates for the FOSQ-10 for adults with excessive daytime sleepiness in narcolepsy or obstructive sleep apnea will be helpful for interpreting changes over time and defining a clinical responder.ClinicalTrials.gov identifiersNCT02348593 (first submitted January 15, 2015) and NCT02348606 (first submitted January 15, 2015)
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
Journal of Clinical Sleep Medicine, Ahead of Print.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Authors: Source Type: research
J Sleep Res. 2021 Jun 24:e13426. doi: 10.1111/jsr.13426. Online ahead of print.ABSTRACTThe analysis of sleep microstructure in attention deficit hyperactivity disorder (ADHD) revealed an under-representation of the EEG slow component during NREM sleep. Previous studies either excluded or did not characterize objectively sleep disorders, which notoriously affect sleep architecture. The present study aimed to investigate the cyclic alternating pattern in a real clinical sample of children with ADHD, in whom sleep disorders could be considered. Twenty-seven consecutively enrolled drug-naïve children (mean age, 10.53 year...
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Source Type: research
Journal of Clinical Sleep Medicine, Ahead of Print.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Authors: Source Type: research
CONCLUSIONS: Narcolepsy in children is a rare neurological syndrome, which can occur with uncommon and atypical clinical presentations. In our case report we aimed to highlight pediatric narcolepsy, which could help to make more appropriate approaches and prevent misdiagnoses or diagnosis delay in these cases.PMID:33929127 | DOI:10.24953/turkjped.2021.02.020
Source: The Turkish Journal of Pediatrics - Category: Pediatrics Authors: Source Type: research
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