Risk prediction models for esophageal cancer: A systematic review and critical appraisal

ConclusionsMost current risk prediction models of esophageal cancer have a high ROB. Prediction models need further improvement in their quality and applicability to benefit esophageal cancer screening.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: REVIEW Source Type: research

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Series Type : Expression profiling by RT-PCROrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by RT-PCR Homo sapiens Source Type: research
ConclusionIpatasertib exhibited rapid absorption and was dose-proportional over a broad dose range. Ipatasertib appeared to be a moderate CYP3A inhibitor when administered at 600  mg and could be administered with or without food in clinical studies.Trail registrationNCT01090960 (registered March 23, 2010); NCT02536391 (registered August 31, 2015).
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
ConclusionOur study did not demonstrate a protective role of vitamin E in decreasing the incidence of CIPN in patients receiving taxane-based chemotherapy. However, the recovery from CIPN was much better as compared to the control arm, which may indicate a role for vitamin E in decreasing the duration and severity of CIPN.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
is a lethal condition where 5-year survival remains at about 15%. There are two main subtypes of oesophageal cancer, squamous cell carcinoma (OSCC) and adenocarcinoma (OAC). OSCC usually affects the middle third of the oesophagus and is associated with smoking, alcohol and low socio-economic status. OAC affects the lower third of the oesophagus and is associated with gastro-oesophageal reflux disease. The UK has the highest incidence of OAC in the world and it is rising. Treatment may be palliative or curative.
Source: Surgery (Medicine Publishing) - Category: Surgery Authors: Tags: Oesophagus and stomach Source Type: research
Publication date: Available online 22 November 2018Source: Best Practice &Research Clinical GastroenterologyAuthor(s): Shao-Hua Xie, Jesper LagergrenAbstractThe two main histological subtypes of oesophageal cancer, squamous cell carcinoma and adenocarcinoma, have distinct risk factor profiles. For oesophageal squamous cell carcinoma, tobacco smoking and excess alcohol use are the main risk factors. For adenocarcinoma, gastro-oesophageal reflux disease and obesity are main risk factors, whereas tobacco smoking is a moderately strong risk factor and infection with Helicobacter pylori decreases the risk. Dietary factors m...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
Abstract Esophageal cancer (EC) presents a high mortality rate, mainly due to its aggressive nature. Squamous cell carcinoma is the most common histological type worldwide, though, a continuous increase in esophageal adenocarcinomas has been noted in the past decades. Common risk factors associated with EC include smoking, alcohol consumption, gastroesophageal reflux disease, Barrett's esophagus and obesity. In an effort to overcome chemotherapy resistance in oncology, it was discovered that histone acetylation/deacetylation equilibrium is altered in carcinogenesis, leading to changes in chromatin structure and al...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
There are two main types of oesophageal cancer, squamous cell carcinoma (SCC) and adenocarcinoma (ACA). SCC usually affects the middle third of the oesophagus and is associated with smoking, alcohol and low socio-economic status. ACA affects the lower third of the oesophagus and is associated with gastro-oesophageal reflux disease. The UK has the highest incidence of ACA in the world and it is rising. Treatment may be palliative or curative. Curative treatment for advanced disease consists of neo-adjuvant chemotherapy or chemoradiotherapy followed by surgery.
Source: Surgery (Medicine Publishing) - Category: Surgery Authors: Tags: Oesophagus and stomach Source Type: research
Abstract Esophageal cancer has a poor prognosis and high mortality rate, with an estimated 16,910 new cases and 15,910 deaths projected in 2016 in the United States. Squamous cell carcinoma and adenocarcinoma account for more than 95% of esophageal cancers. Squamous cell carcinoma is more common in nonindustrialized countries, and important risk factors include smoking, alcohol use, and achalasia. Adenocarcinoma is the predominant esophageal cancer in developed nations, and important risk factors include chronic gastroesophageal reflux disease, obesity, and smoking. Dysphagia alone or with unintentional weight los...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
Conclusion Adenocarcinoma and squamous cell carcinoma are different diseases, but both are diagnosed in advanced stages in Brazil, compromising the patients' possibilities of cure.RESUMO Contexto Câncer esofágico é uma das principais causas de morte por câncer dentre as neoplasias do trato gastrointestinal. Há diversos fatores que contribuem para o desenvolvimento de um perfil epidemiológico de câncer de esôfago em uma população. Objetivo Este estudo visa descrever tanto clínica quanto epidemiologicamente a população de pacientes com dia...
Source: Arquivos de Gastroenterologia - Category: Gastroenterology Source Type: research
Publication date: April 2016 Source:Cancer Epidemiology, Volume 41 Author(s): Aaron P. Thrift Since the early 1970s, the incidence of oesophageal adenocarcinoma has increased dramatically in most Western populations. In contrast, the incidence of oesophageal squamous-cell carcinoma has decreased in these same populations. Epidemiological studies conducted over the past decade have provided great insights into the etiology of oesophageal cancer. These studies have identified gastro-oesophageal reflux disease, obesity and cigarette smoking as risk factors for oesophageal adenocarcinoma, while use of nonsteroidal anti-infl...
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
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