Africa: Microbe Discovery 'Could Halt Malaria Transmission'

[SciDev.Net] A microbe that is transmitted between male and female mosquitoes but can also block reproduction could be key to controlling malaria by targeting its release into mosquito populations, a study says.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news

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Conclusion: The study identified some individual and contextual predictors of malaria among children in Nigeria. These factors identified in this study are potential areas that need to be considered for policy designs and implementations toward control and total elimination of malaria-related morbidity and mortality among children in Nigeria.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
This study aimed to quantify G6PDd prevalence in two geographically distinct areas in Sudan, and evaluating the performance of a qualitative CareStart rapid diagnostic test as a point-of-care test. Blood samples were analyzed from 491 unrelated healthy persons in two malaria-endemic sites in eastern and central Sudan. A pre-structured questionnaire was used which included demographic data, risk factors and treatment history. G6PD levels were measured using spectrophotometry (SPINREACT) and first-generation qualitative CareStart rapid tests. G6PD variants (202 G>A; 376 A>G) were determined by PCR/RFLP, with a subset c...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
CONCLUSIONS: In addition to increasing predictive power, the new continuous urbanicity metric provided a clearer mechanistic understanding than the dichotomous urban/rural designations. Such designations often ignore urban-like, low-risk pockets within traditionally rural areas, as were found in Malawi, along with rural-like, potentially high-risk environments within urban areas. This method of characterizing urbanicity can be applied to other infectious disease processes in rapidly urbanizing contexts.PMID:34689786 | DOI:10.1186/s12936-021-03950-5
Source: Rural Remote Health - Category: Rural Health Authors: Source Type: research
Evid Based Complement Alternat Med. 2021 Oct 13;2021:2089114. doi: 10.1155/2021/2089114. eCollection 2021.ABSTRACTBACKGROUND: Different parts of Brucea antidysenterica are used in traditional and alternative medicine in Ethiopia for the treatment of different health problems including malaria and have good in vitro antimalarial activity. However, no in vivo study was conducted to substantiate the claim. Our study planned to determine the antimalarial effect of B. antidysenterica extract.METHODS: Swiss albino mice (6-8 weeks old, 20-28 g) were inoculated with Plasmodium berghei. Different doses of both hydromethanolic extra...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Source Type: research
A child health consultation at Obunga Dispensary in Homa Bay, one of the eight counties participating in the malaria vaccine pilot program. Credit: Joyce Chimbi/IPSBy Joyce ChimbiNairobi, Kenya, Oct 25 2021 (IPS) One morning in 2016, Lillian Nekesa’s 3-year-old woke up with flu-like classic symptoms of malaria. This was not Kevin’s first encounter with the killer disease. Kevin was nonetheless not immediately rushed to Busia County Referral Hospital for advanced treatment in keeping with his severe symptoms. Nekesa rushed him to a village dispensary because the referral hospital is an hour’s walk away fr...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Africa COVID-19 Development & Aid Featured Headlines Health Human Rights Inequity TerraViva United Nations ​#Health​ #MalariaVaccine Kenya Source Type: news
[WHO] Virtual forum also features presentations on new vaccine candidates
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
This study provides relevant knowledge on malaria transmission dynamics by using a genomic approach to identify mosquito genes associated with susceptibility to Plasmodium infection in Ny. darlingi in western Amazonian Brazil.
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
Malaria, caused by Plasmodium (P.) parasite species, poses a significant global health burden. There were 229 million malaria cases reported in 2019 and 95% of the 409,000 global malaria-caused fatalities occurred in sub-Saharan Africa (World Malaria Report 2020). Infection of the human host begins with a Plasmodium-infected mosquito bite that deposits sporozoites in the skin. Sporozoites enter blood vessels, are transported to the liver and invade hepatocytes. Within a hepatocyte, each sporozoite transforms into a liver stage (LS), which differentiates into tens of thousands of exo-erythrocytic merozoites.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Hepatology Snapshot Source Type: research
by Anja C. Schlott, Ellen Knuepfer, Judith L. Green, Philip Hobson, Aaron J. Borg, Julia Morales-Sanfrutos, Abigail J. Perrin, Catherine Maclachlan, Lucy M. Collinson, Ambrosius P. Snijders, Edward W. Tate, Anthony A. Holder We have combined chemical biology and genetic modification approaches to investigate the importance of protein myristoylation in the human malaria parasite,Plasmodium falciparum. Parasite treatment during schizogony in the last 10 to 15 hours of the erythrocytic cycle with IMP-1002, an inhibitor ofN-myristoyl transferase (NMT), led to a significant blockade in parasite egress from the infected erythro...
Source: PLoS Biology: Archived Table of Contents - Category: Biology Authors: Source Type: research
kakibara Artisanal and small-scale gold mining (ASGM) has a known negative effect on the community’s health; therefore, assessment to monitor community health is essential to detect any issues and enable early treatment. Because ASGM-related health issues are complex and cannot be addressed effectively with a traditional one-time health assessment alone, both long-term and regular health assessments using a transdisciplinary approach should be considered. In response to this need, we designed an online health assessment tool as a reference for a future long-term health assessment system. An online video interview...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Case Report Source Type: research
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