Management Considerations for Lipid Disorders During Pregnancy

AbstractPurpose of reviewDyslipidemias including familial hypercholesterolemia and elevated lipoprotein (a) are not uncommon in young women who may desire pregnancy. In all women, abnormal lipid metabolism has been linked to adverse outcomes during pregnancy, including hypertensive disease of pregnancy, gestational diabetes mellitus, and preterm birth. Optimal management of dyslipidemias in pregnant women remains undefined, as statins are contraindicated in this group.Recent findingsRecent literature questions this traditional avoidance of statins, however, as well as explores their potential benefit in pre-eclampsia specifically.SummaryIn this review, the arsenal of nutrition, bile acid resins, omega-3 fatty acids, and low-density lipoprotein cholesterol apheresis is explored, as are newer therapies like mipomersen and proprotein convertase subtilisin/kexin type 9 inhibitors, for the management of dyslipidemias during pregnancy.
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research