Clinical, radiographic features and long-term outcomes of paradoxical cryptococcosis-associated immune reconstitution inflammatory syndrome secondary to the ventriculoperitoneal shunt

Paradoxical immune reactions in cryptococcal meningitis (CM), also termed as cryptococcal-immune reconstitution inflammatory syndrome (C-IRIS), occurs in 13% –30% of immunodeficiency individuals with CM receiving antifungal therapy and antiretroviral therapy(ART).1,2 However, in recent years, isolated cases and small case series of IRIS have also been reported in immunocompetent CM hosts with varying frequencies.3,4 IRIS manifestations include deterior ation of clinical manifestations and neuroimaging abnormalities, as well as changes in cerebrospinal fluid after clinical and/or microbial responses to anti-cryptococcal therapy.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research