Gamma-H2AX Foci Decay Ratio as a Stronger Predictive Factor of Late Radiation Toxicity than Dose-Volume Parameters in a Prospective Cohort of Prostate Cancer Patients

Late radiation toxicity is a major dose-limiting factor in curative cancer radiotherapy. Previous studies identified several risk factors for late radiation toxicity, including both dose-volume factors and genetic predisposition. Herein, we investigated the contribution of genetic predisposition, particularly compared to dose-volume factors, to the risk of late radiation toxicity in patients treated with highly conformal radiotherapy.

Source: International Journal of Radiation Oncology * Biology * Physics - August 19, 2021 Category: Radiology Authors: Anna C. Nuijens, Arlene L. Oei, Bregje van Oorschot, Jorrit Visser, Rob M. van Os, Perry D. Moerland, Nicolaas A.P. Franken, Coen R.N. Rasch, Lukas J.A. Stalpers Source Type: research