The RATIOnal Role of Polyamines in Epidermal Differentiation

Polyamines have been implicated in skin tumorigenesis; however, their role in epidermal homeostasis remains obscure. In a new article in the Journal of Investigative Dermatology, Rahim et  al. (2021) report that keratinocyte differentiation requires a shift in polyamine ratios that is mediated by AMD1. Results suggest that targeting polyamine availability might be useful in the treatment of hyperproliferative skin disorders.

Source: Journal of Investigative Dermatology - August 19, 2021 Category: Dermatology Authors: Kira Allmeroth, Martin S. Denzel Tags: Commentary Source Type: research