LB711 Characterizing Skin Resident Memory T cell formation in Murine Cutaneous Lupus Erythematosus

Cutaneous Lupus Erythematosus (CLE) is a spectrum of autoimmune connective tissue diseases that are characterized histopathologically by interface dermatitis and lupus band reaction. Current treatment options for CLE are based on SLE treatments and include topical steroids, antimalarials, and other immunosuppressants. Many CLE patients exhibit flares which can be triggered by environmental stimuli such as UV light. Tissue-resident memory T cells (Trm) mediate flares in autoimmune skin disorders, though their specificities, functional molecules, and survival factors in CLE have not yet been described.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Source Type: research