Very early glucose tolerance abnormalities in children with cystic fibrosis
Pancreatic injury in cystic fibrosis (CF) begins in utero, as evidenced by an increase in immunoreactive trypsinogen values in new-born screening. Cystic-fibrosis-related diabetes (CFRD), a comorbidity of CF, differs from Type 1 or Type 2 diabetes mellitus. It occurs primarily due to impaired insulin secretion and worsens prognosis, because it is associated with decreased lung function and poor nutritional status . Dysglycaemia frequency increases over time amongst children, adolescents and young adults.