This Breast Cancer Gene Is Less Well Known, but Nearly as Dangerous

PALB2 is not as well known as BRCA, but mutations of the gene can raise a woman ’s risk for breast cancer almost as much.
Source: NYT Health - Category: Consumer Health News Authors: Tags: your-feed-science Breast Cancer Genetics and Heredity Tests (Medical) Pancreatic Cancer Ovarian Cancer Women and Girls American College of Medical Genetics your-feed-healthcare Source Type: news

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Conclusions: Non-BRCA gene mutations are frequently identified in breast cancer patients with high risk factors. Family history showed a correlation with both BRCA (p = 0.005) and non-BRCA HRR gene mutation status (p = 0.036), so we strongly suggest that breast cancer patients with a BRCA-related family history receive comprehensive gene mutation testing in China, especially HRR genes, which are not only related to high risk of breast cancer, but also potentially related to poly ADP ribose polymerase inhibitor (PARPi) targeted therapy. The exact relationship of rare gene mutations to breast cancer predisposition and the pa...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Phytother Res. 2021 Nov 22. doi: 10.1002/ptr.7325. Online ahead of print.ABSTRACTOleuropein is an ester of elenolic acid and hydroxytyrosol (3, 4-dihydroxyphenylethanol). It is a phenolic compound and the most luxuriant in olives. The detailed information related to the anticancer effects of oleuropein was collected from the internet database PubMed/Medline, ResearchGate, Web of Science, Wiley Online Library, and Cnki using appropriate keywords until the end of October 2021. Oleuropein has been shown to have antioxidant, anticancer, antiinflammatory, cardioprotective, neuroprotective, and hepatoprotective effects. Previous...
Source: Cell Research - Category: Cytology Authors: Source Type: research
CONCLUSION: Biallelic alterations in core HRR-associated genes are frequent, strongly associated with elevated gLOH, and enriched in breast, ovarian, pancreatic, and prostate cancer. This analysis could inform the design of the next generation of clinical trials examining DNA repair-targeting agents, including poly-ADP ribose polymerase inhibitors.PMID:34740923 | DOI:10.1158/1078-0432.CCR-21-2096
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Source Type: research
ConclusionsStroke incidence is significantly increased after diagnosis of certain cancers.Implications for Cancer SurvivorsCardiovascular risk should be assessed during cancer survivorship care, with attention to modifying shared cancer/cardiovascular risk factors.
Source: Journal of Cancer Survivorship - Category: Cancer & Oncology Source Type: research
Neoplasma. 2021 Nov 4:210226N252. doi: 10.4149/neo_2021_210226N252. Online ahead of print.ABSTRACTCell-based therapies cure some hematologic malignancies, although little information exists on solid cancer cell responses. The study objective was to test the hypothesis that xenogeneic fibroblasts can inhibit the growth of human cancer cell lines in vitro. Seven human cell lines (pancreatic cancer HPAF II; brain cancer U-87 MG; fibrosarcoma; ovarian cancer OVCAR3 and SKOV3; and breast cancer MCF7 and MDA-MB231) were co-cultured with two xenogeneic fibroblast cell lines (CV-1; monkey, Cercopithecus aethiops and DF-1; chicken,...
Source: Neoplasma - Category: Cancer & Oncology Authors: Source Type: research
Pathol Res Pract. 2021 Oct 21;228:153663. doi: 10.1016/j.prp.2021.153663. Online ahead of print.ABSTRACTDOG1 (Discovered on GIST1) is a voltage-gated calcium-activated chloride and bicarbonate channel that is highly expressed in interstitial cells of Cajal and in gastrointestinal stromal tumors (GIST) derived from Cajal cells. To systematically determine in what tumor entities and normal tissue types DOG1 may be further expressed, a tissue microarray (TMA) containing 15,965 samples from 121 different tumor types and subtypes as well as 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. DO...
Source: Pathology, Research and Practice - Category: Pathology Authors: Source Type: research
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