Association of maternal diabetes during pregnancy with high refractive error in offspring: a nationwide population-based cohort study

AbstractAims/hypothesisWe aimed to investigate the associations between maternal diabetes before or during pregnancy and the risk of high refractive error (RE) in offspring until the age of 25  years.MethodsThis nationwide register-based cohort study comprised 2,470,580 individuals born in 1977 –2016. The exposure was maternal diabetes during or before pregnancy (type 1 diabetes, type 2 diabetes and gestational diabetes). Cox regression was used to examine the association between maternal diabetes and the risk of high RE in offspring from birth until the age of 25 years, adjusting for m ultiple potential confounders.ResultsDuring up to 25  years of follow-up, 553 offspring of mothers with diabetes and 19,695 offspring of mothers without diabetes were diagnosed with high RE. Prenatal exposure to maternal diabetes was associated with a 39% increased risk of high RE: HR 1.39 (95% CI 1.28, 1.51),p 
Source: Diabetologia - Category: Endocrinology Source Type: research

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