Twenty-four hour assessments of substrate oxidation reveal differences in metabolic flexibility in type 2 diabetes that are improved with aerobic training

Conclusions/interpretationTwenty-four hour WRIC revealed that physiological RQ responses exemplify differences in MetFlex across a spectrum of metabolic health and correlated with skeletal muscle mitochondrial energetics. Defects in certain features of MetFlex were improved with aerobic training, emphasising the need to assess multiple aspects of MetFlex and disentangle insulin resistance from MetFlex in type 2 diabetes.Trial registrationClinicalTrials.gov NCT01911104.FundingThis study was funded by the ADA (grant no. 7-13-JF-53).Graphical abstract
Source: Diabetologia - Category: Endocrinology Source Type: research