Compounded with hemoglobin Port Phillip and ‐α4.2 or ‐‐SEA deletions were identified in Chinese population

ConclusionHere we first time identified two patients compound with Hb Port Phillip and - α4.2 and --SEA deletions, respectively, which had never been reported. Our study widens the genotypes of hemoglobinopathy and provides reference for genetic counselling and prenatal diagnosis in this population.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: CLINICAL REPORT Source Type: research

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Int J Biol Macromol. 2021 Sep 29;191:764-774. doi: 10.1016/j.ijbiomac.2021.09.122. Online ahead of print.ABSTRACTA hypoxia-responsive pullulan-based co-polymer was developed to assess its efficacy to deliver erlotinib (ERL) to the cervical cancer cells. Upon exposure to hypoxic condition, the synthesized and structurally characterized co-polymer i.e. succinyl pullulan-g-6-(2-nitroimidazole) hexylamine (Pull-SA-HA-NI) exhibited a hypochromic shift in the UV spectra and alteration in its self-assembled structures as compared to the control co-polymer, succinyl pullulan-g-hexylamine (Pull-SA-HA). Its corresponding ERL-loaded ...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Source Type: research
ConclusionZaghloul 2 formula showed the highest efficacy in the differentiation of β-TT from IDA (85%) followed by MCI (74%) and MDHL (72%) then England and Fraser (68%) and lastly MCHD (66%). They can be used for screening in big population, being simple and inexpensive, and then followed by the usual confirmatory tests. Their real use comes in rural areas and primary care facil ities where only red blood cell indices are handy. They can be calculated and the cases can be referred to secondary health care to take the confirmatory tests for diagnosis.
Source: QJM - Category: Internal Medicine Source Type: research
CONCLUSION: The commonly available parameters of the CBC predict in-hospital mortality. Addition of the proportions of hypochromic red cells, macrocytic red cells, and large unstained cells may improve the predictive value of the CBC.PMID:34464032 | DOI:10.1111/ijlh.13684
Source: International Journal of Laboratory Hematology - Category: Hematology Authors: Source Type: research
AbstractThe interconnection of scientific studies and art represented by Leonardo Da Vinci ’s (1452–1519) portraiture accentuates his role in documenting and archiving dermatologic conditions. His anatomical dissections, sketches, and paintings, including portraits, were all a means to observe, portray, and understand the nuances of the human body. In two of his most discussed portrai ts,Ginevra de ’ Benci (1474-1478) andElisabetta del Giocondo, the Mona Lisa (1503-1506), Leonardo ’s execution of the exterior anatomy is so precise that he may have illustrated manifestations of disease that...
Source: Journal of Medical Humanities - Category: Medical Ethics Source Type: research
To create neonatal reference intervals for the MicroR and HYPO-He complete blood count (CBC) parameters and to test whether these parameters are sensitive early markers of disease at early stages of microcytic/hypochromic disorders while the CBC indices are still normal.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Original Articles Source Type: research
To create neonatal reference intervals for the “Micro-R” and “HYPO-He” CBC parameters and to test whether, at early stages of microcytic/hypochromic disorders, while the CBC indices are still normal, these parameters are sensitive, early markers of disease.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Original Articles Source Type: research
J Environ Public Health. 2021 Jul 15;2021:7283514. doi: 10.1155/2021/7283514. eCollection 2021.ABSTRACTThis exploratory, descriptive cohort study (N = 60) determined lead (Pb) and arsenic (As) blood concentrations in Peruvian children and their association with hematological parameters of iron-deficient anemia (IDA) and anthropometric measurement. The mean age of children was 10.8 months (SD = 4.7) and ranged from 3 to 24 months old. Anemia (Hb levels below 10.5 g/dL) was found in 20% of this cohort. Additionally, microcytosis (MCV
Source: Journal of Environmental and Public Health - Category: Environmental Health Authors: Source Type: research
CONCLUSION: Extended red cell analysis delivered by the advanced optical technology on the Alinity hq hematology analyzer has efficient diagnostic utility in the initial discrimination of the two most common microcytic anemias: IDA and β-thalassemia trait.PMID:34337874 | DOI:10.1111/ijlh.13663
Source: International Journal of Laboratory Hematology - Category: Hematology Authors: Source Type: research
Skinmed. 2021 Jun 1;19(3):229-231. eCollection 2021.ABSTRACTOur patient was a 43-year-old, single black woman, born and living in Paracambi, State of Rio de Janeiro, who worked as a surgical instrumentalist. She was sent to our sector of dermatology due to hypochromia and diffuse skin roughness that had first appeared 8 years previously. She had been diagnosed 6 months before admission with ductal infiltrating metastatic carcinoma in the right breast, with therapeutic failure of chemotherapy and radiotherapy. Her menarche had occurred at age 13 years, she reported normal menstrual cycles from there on, and she had never be...
Source: Skinmed - Category: Dermatology Authors: Source Type: research
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