Acute arthritis of the right temporomandibular joint due to Lyme disease: a case report and literature review

Lyme disease is the most frequent tick-borne infectious disease in Europe. It often presents with a wide variety of symptoms. For this reason, affection of the temporomandibular joint (TMJ) caused by Lyme dise...
Source: BMC Oral Health - Category: Dentistry Authors: Tags: Case report Source Type: research

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ConclusionThe therapy is based on arthroscopic or open surgical debridement for synovectomy and irrigation of the joint, in combination with an adequate antibiotic therapy for 6 –12 weeks. Removal of indwelling hardware, such as interference screws for ACL repair or anchors for rotator cuff repair, is recommended in chronic cases.Level of evidenceIV.
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
Conditions:   Rheumatoid Arthritis;   Non-Alcoholic Steatohepatitis Interventions:   Drug: LB-P6, Cohort 1;   Drug: LB-P8, Cohort 1;   Drug: Placebo, Cohort 1;   Drug: LB-P6, Cohort 2;   Drug: LB-P8, Cohort 2;   Drug: Placebo, Cohort 2 Sponsors:   LISCure Biosciences AUS Pty LTD;   Novotech (Australia) Pty Limited Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: This integrated safety analysis provides relevant information for clinicians treating patients with psoriasis, PsA, or axSpA with ixekizumab. No new safety signals were identified in patients receiving ixekizumab.PMID:34547967 | DOI:10.1080/09546634.2021.1976375
Source: Journal of Dermatological Treatment - Category: Dermatology Authors: Source Type: research
Conclusion: Patients with skin psoriasis exhibit DNA methylation patterns in CD8+ T cells that allow differentiation from PsA patients and healthy individuals, and reflect clinical activity of skin disease. Thus, DNA methylation profiling promises potential as diagnostic and prognostic tool to be used for molecular patient stratification towards individualized treatment.This project aimed at the identification of disease-/outcome-specific DNA methylation signatures in CD8+ T cells from patients with psoriasis and PsA as compared to heathy controls.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Methylation profiling by genome tiling array Homo sapiens Source Type: research
NEW YORK (Reuters Health)—Lower doses of cannabidiol (CBD) failed to provide any meaningful reduction in pain when added to other analgesic therapy in patients with hand osteoarthritis (OA) or psoriatic arthritis (PsA) in a randomized, placebo-controlled study from Denmark.1 Writing in the journal, Pain, Jonathan Vela, MD, and colleagues of Aalborg University note that CBD... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Analgesics Drug Updates cannabidiol (CBD) hand osteoarthritis hand pain PsA Psoriatic Arthritis Source Type: research
Objective: To evaluate the efficacy and safety of metformin use in rheumatoid arthritis (RA) patients receiving conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs).Methods: A prospective, randomized, controlled, single blinded, study was carried on 66 RA patients with moderate and high disease activity state, receiving csDMARDs. Patients were simply randomized to receive either metformin 850 mg twice daily (Metformin group, n = 33), or placebo twice daily (Control group, n = 33) in addition to their stable anti-rheumatic regimen and followed up for 6 months. Serum C-reactive protein (CRP), disease...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Auranofin is an FDA-approved disease-modifying anti-rheumatic drug that has been used for decades for treatment of rheumatoid arthritis. This gold(I) compound has anti-inflammatory properties because it reduces IL-6 expression via inhibition of the NF-κB-IL-6-STAT3 signaling pathway. Also, by inhibiting redox enzymes such as thioredoxin reductase, auranofin increases cellular oxidative stress and promotes apoptosis. Auranofin also possesses antiviral properties. Recently, it was reported that auranofin reduced by 95% SARS-CoV-2 RNA in infected human cells in vitro and decreased SARS-CoV-2-induced cytokine expression,...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
IJERPH, Vol. 18, Pages 9948: The Combination of Modified Mitchell’s Osteotomy and Shortening Oblique Osteotomy for Patients with Rheumatoid Arthritis: An Analysis of Changes in Plantar Pressure Distribution International Journal of Environmental Research and Public Health doi: 10.3390/ijerph18199948 Authors: Hyunho Lee Hajime Ishikawa Tatsuaki Shibuya Chinatsu Takai Tetsuya Nemoto Yumi Nomura Asami Abe Hiroshi Otani Satoshi Ito Kiyoshi Nakazono Kaoru Abe Kazuyoshi Nakanishi Akira Murasawa The present study aims to evaluate changes in plantar pressure distribution after joint-preserving...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
AbstractAim of this study was to evaluate and compare the efficacy of anti-arthritic drugs (naproxen, prednisolone, and hydroxychloroquine) alone and in combination. The in vitro anti-arthritic activity was evaluated by stabilization of human erythrocytes (HRBCs) membrane assays. In vivo activity was carried out using Complete Freund ’s Adjuvant (CFA) induced arthritic model in Wistar rat. Individual and combination drugs were administered for 21 days in rats 8 days post inoculation with CFA (0.15 ml injected in right hind paw). Body weight and paw edema were measured at different intervals. Combinatio...
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research
Rhythmic joint mobilizations (RJM) of the temporomandibular joint (TMJ) are employed to relieve pain and improve function in patients with temporomandibular disorders (TMD). However, the evidence on the immediate effects of RJM in patients with TMD is scarce. The aim of this study was to assess the immediate clinical and functional effects of RJM in patients with TMD.
Source: Journal of Bodywork and Movement Therapies - Category: Physiotherapy Authors: Tags: Myofascial Pain and Treatment Source Type: research
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