Efficacy of Escalated Anti-TNF Therapy in Crohn's Disease Efficacy of Escalated Anti-TNF Therapy in Crohn's Disease

Is dose escalation of anti-TNF therapy effective for reestablishing clinical response in Crohn's disease?Alimentary Pharmacology &Therapeutics
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

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CROHN'S disease is a painful inflammatory condition which presents a variety of unusual symptoms. What are the two commonly reported signs?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
aczmarek Andrzej Radzikowski Jarosław Walkowiak The human leukocyte antigen (HLA) allele group HLA-DQA1*05 predisposes to ulcerative colitis (UC) and is associated with the development of antibodies against infliximab in patients with inflammatory bowel disease (IBD). Therefore, we hypothesized that the presence of HLA-DQA1*05 correlates with characteristics of pediatric IBD. Within a multi-center cohort in Poland, the phenotype at diagnosis and worst flare was established and HLA-DQA1*05 status was assessed enabling genotype-phenotype analyses. HLA-DQA1*05 was present in 221 (55.1%) out of 401 children with IBD (...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
CONCLUSIONS: We found low certainty evidence that transcranial direct current stimulation may improve pain intensity compared to sham stimulation. We could not reach any conclusions on the efficacy of any other interventions on pain intensity, pain frequency, and treatment success. The certainty of the evidence was very low due to the low numbers of studies and participants in each comparison and clinical heterogeneity amongst the studies. While no serious or total adverse events were elicited explicitly with any of the treatments studied, the reported events were very low. The certainty of the evidence for all comparisons...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Source Type: research
CONCLUSIONS: The current study showed BAE is a very useful modality for detecting MD compared with other conventional modalities.PMID:34840565 | PMC:PMC8616713 | DOI:10.1155/2021/9574737
Source: Gastroenterology Research and Practice - Category: Gastroenterology Authors: Source Type: research
CONCLUSION: HPM improves CD-associated intestinal fibrosis by suppressing the RhoA/ROCK1/MLC pathway.PMID:34840583 | PMC:PMC8612780 | DOI:10.1155/2021/2247953
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Source Type: research
CONCLUSIONS: The current study showed BAE is a very useful modality for detecting MD compared with other conventional modalities.PMID:34840565 | PMC:PMC8616713 | DOI:10.1155/2021/9574737
Source: Gastroenterology Research and Practice - Category: Gastroenterology Authors: Source Type: research
This article discusses early diagnosis, disease severity and classification, familial predisposition and genomics, and clinical management in the primary care setting.
Source: The Nurse Practitioner - Category: Nursing Tags: Feature: GASTROINTESTINAL DISORDERS: NCPD Connection Source Type: research
AbstractBackgroundInter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) plays vital roles in inflammatory and auto-immune diseases, but its correlations with disease risk and clinical features in inflammatory bowel disease (IBD) need further investigation. The present study intended to explore the correlation of ITIH4 with disease activity and inflammation, as well as its change after treatment in IBD patients.MethodsTotally, 40 active Crohn ’s disease (A-CD) patients, 40 clinical-remission CD (R-CD) patients, 40 active ulcerative colitis (A-UC) patients, 40 clinical-remission UC (R-UC) patients, and 40 health controls...
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
CROHN'S disease is the painful digestive condition with unusual warning signs. The colour of your poo being one of them. What to look out for?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
In this study, we described a unique case of cutaneous metaplasia on the elbow of a 25-year-old man who had a clinical history of epidermolysis bullosa simplex, but had no history of any gastrointestinal disease. The lesion had been clinically stable for 5 years. Histopathologically, the epithelium showed many columnar cells with mucinous cytoplasm, with no atypia or mitoses. The proliferation rate was low (7% by Ki67). The metaplastic areas expressed epithelial membrane antigen, carcinoembryonic antigen, cytokeratin 7, MUC5AC, MUC2, and Cyclin-D1.
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Extraordinary Case Report Source Type: research
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