O-146 Assessment of focal and diffuse adenomyosis lesions before and after pregnancy on magnetic resonance imaging : a cohort of 139 patients

AbstractStudy questionHow to assess the different adenomyosis phenotype before and after pregnancy on magnetic resonance imaging according to stringent validated criteria ?Summary answerDiffuse adenomyosis increases significantly after pregnancy while the rate of focal adenomyosis and the mean volume of focal adenomyosis lesions decrease significantly after pregnancy.What is known alreadyAdenomyosis and endometriosis are benign hormone-dependent disorders associated with pelvic pain, dysmenorrhea and/or infertility. The natural course of adenomyosis and endometriosis is still unclear, particularly during pregnancy. Pregnancy is considered to have a positive impact on endometriosis. Several studies regarding the impact of adenomyosis on pregnancy are available. Adenomyosis can cause fertility disorders, miscarriage, preterm birth. However, available data evaluating the effect of pregnancy on adenomyosis are lacking.Study design, size, durationBetween January 1st 2010 and September 30th 2020, 139 patients were followed in our referral care center (Gynecology department of Port-Royal Hospital, Paris) for symptomatic adenomyosis and or endometriosis. For each of them, a magnetic resonance imaging were performed before and after pregnancy. The data based on magnetic resonance imaging, pre- and post-pregnancy, were analyzed in a single retrospective study.Participants/materials, setting, methodsPatients had to be over 18 years old, to be pregnant and to be followed for symptomatic ...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research

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CONCLUSIONS: No studies reported on our primary outcome of live birth rate. Due to the very limited evidence, we are uncertain of the effects of pentoxifylline on clinical pregnancy rate, miscarriage rate, or overall pain. There is currently insufficient evidence to support the use of pentoxifylline in the management of women with endometriosis with respect to subfertility and pain relief outcomes.PMID:34431079 | DOI:10.1002/14651858.CD007677.pub4
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Source Type: research
This study is a retrospective, non-interventional monocentric cohort study conducted between January 2011 and December 2017 in Institut de Medecine de la Reproduction - Clinique Bouchard in Marseilles, France.Participants/materials, setting, methodsThe outcome of pregnancies obtained after IVF and/or ICSI in patients with endometriosis (n  = 270) was compared with patients,free of endometriosis,monitored for male infertility (n = 366) The statistical study was carried out using GraphPad Version 8 The Student T-test was used to compare means across them. Results were considered significant for p&...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
While endometriosis is a common condition, affecting as many as one in every 10 American women, it is complex and often misunderstood. Endometriosis occurs when tissue much like the tissue that normally lines the uterus — called the endometrium — starts to grow elsewhere in the body. These growths may cause pain, scarring, and, in some instances, infertility. One study shows it can take up to seven years for a woman to get a diagnosis of endometriosis because symptoms may mimic other common conditions, such as irritable bowel syndrome or pelvic inflammatory disease. And misconceptions about the disease, includi...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Adolescent health Pain Management Women's Health Source Type: blogs
CONCLUSIONS: Compared to diagnostic laparoscopy only, it is uncertain whether laparoscopic surgery reduces overall pain associated with minimal to severe endometriosis. No data were reported on live birth. There is moderate quality evidence that laparoscopic surgery increases viable intrauterine pregnancy rates confirmed by ultrasound compared to diagnostic laparoscopy only. No studies were found that looked at live birth for any of the comparisons. Further research is needed considering the management of different subtypes of endometriosis and comparing laparoscopic interventions with lifestyle and medical interventions. ...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
CONCLUSIONS: Using robust consensus science methods, healthcare professionals, researchers, and women with endometriosis have developed a core outcome set to standardise outcome selection, collection, and reporting across future randomised controlled trials and systematic reviews evaluating potential treatments for endometriosis. TWEETABLE ABSTRACT: @coreoutcomes for future #endometriosis research have been developed @jamesmnduffy. PMID: 32227676 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
While infertility may be a problem affecting nearly 7.3 million women in the United States between the ages of 15-44, it is a topic that women often don’t discuss. Rather, they suffer from the emotional pain that accompanies hormone injections, multiple procedures, and sometimes miscarriage. How is it best to treat this vulnerable population that rarely gets the attention it deserves? The answer lies in a team approach to medicine. According to Dr. Michael Jacobs, reproductive endocrinologist and infertility expert, who is director of Fertility and IVF Center of Miami, “The best way to treat couples challenged ...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions OB/GYN Source Type: blogs
Andrea Syrtash was first hospitalized at the age of 14 for painful and heavy menstrual cycles due to endometriosis. She had no idea her condition would affect her fertility ― and even if she had known, she may not have thought to address it without guidance from her doctors. After six years of trying to conceive, Syrtash, who’s now in her 40s and works as a relationship and dating expert, recently founded pregnantish, a website for singles, couples and LGBTQ people who are trying to conceive.  “When you’re a teenager, it’s not on your mind,” she said. Had she known, “I migh...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
This article addresses causes of abdominal pain in pregnancy such as miscarriage, ectopic pregnancy, fibroids and urinary tract infection. In the non-pregnant female, cyclical causes of pain include primary dysmenorrhoea, endometriosis and mittelschmerz; and non-cyclical causes include pelvic inflammatory disease, ovarian cyst accidents and adhesions. An ovarian cyst accident occurs when an ovarian cyst undergoes torsion, bleeds internally or ruptures. Timely diagnosis is prudent in order to avoid ovarian infarction and hence loss of ovarian tissue, especially in a young woman. Pelvic inflammatory disease is the reason for...
Source: Surgery (Oxford) - Category: Surgery Source Type: research
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