P-745 The efficacy of Buscopan ® in reducing pain during ultrasound-guided manual vacuum aspiration (USG-MVA): A double-blind randomised placebo-controlled trial

AbstractStudy questionDoes Buscopan ® reduce abdominal pain experienced by women undergoing ultrasound-guided manual vacuum aspiration (USG-MVA)?Summary answerThe addition of 20mg Buscopan ® intravenous injection was not associated with a statistical reduction in pain score but leads to a higher patient satisfaction score.What is known alreadyUltrasound-guided Manual Vacuum aspiration is a feasible and effective out-patient treatment option for treating early pregnancy loss. However, it is associated with a moderate amount of pain due to uterine contraction.Study design, size, durationThis randomised, double-blinded, placebo-controlled trial was conducted in a university-affiliated tertiary hospital. The study assessed whether 1  ml of 20mg Buscopan® intravenous injection 5 minutes before the USG-MVA will reduce the abdominal pain experienced by the women immediately and 2 hours after the procedure. Participants were randomised between June 2018 to January 2020 using a computer-generated number series in a 1:1 ratio.Participants/materials, setting, methodsWomen aged 18 years or older with first-trimester miscarriage undergoing the USG-MVA procedure were eligible. In total, 122 participants out of 128 eligible were included. Of whom, 111 underwent the USG-MVA procedure, 60 randomised to the Buscopan ® group, and 62 to the placebo group.Main results and the role of chanceThe median abdominal pain scores in the Buscopan ® group were 16.0%...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research

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We report a case of 32-year-old woman, gravida 6 para 3 with a history of two previous miscarriages. She presented with a pelvic pain to our emergency department. She was hemodynamically stable with a beta human chorionic gonadotropin serum level of 26342 IU/L. Ultrasound was suspicious for an interstitial pregnancy (Figure 1). After patient consent, surgical management was decided considering her obstetrical history. She underwent an explorative laparoscopy; a non-ruptured left cornual pregnancy was found (Figure 2).
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: IMAGES IN Gynecological Surgery Source Type: research
AbstractStudy questionDoes Buscopan ® reduce abdominal pain experienced by women undergoing ultrasound-guided manual vacuum aspiration (USG-MVA)?Summary answerThe addition of 20mg Buscopan ® intravenous injection was not associated with a statistical reduction in pain score but leads to a higher patient satisfaction score.What is known alreadyUltrasound-guided Manual Vacuum aspiration is a feasible and effective out-patient treatment option for treating early pregnancy loss. However, it is associated with a moderate amount of pain due to uterine contraction.Study design, size, durationThis randomised, double-blinde...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionHas the COVID –19 pandemic and public health guidance impacted referrals, outcome and management of early pregnancy in the emergency room?Summary answerCOVID –19 changed the way in which women sought guidance and accessed services in early pregnancy.What is known alreadySpontaneous miscarriage is the most common complication of pregnancy1. Experiencing an early pregnancy loss is often an unexpected and difficult time that can be physically traumatising2. A previous study looking at the experience of a miscarriage from both the female and male point of view identified that long waiting time...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionWhat are the risk factors for early pregnancy loss (EPL) after in vitro fertilization-embryo transfer (IVF-ET)?Summary answerThe maternal age, gestational sac diameter, embryonic length, yolk sac diameter, heart rate of day 27 –29 and endometrium thickness on transfer day were risk factors. What is known already: The first routine ultrasound scan is commonly arranged on day 27–29 after IVF-ET in most reproductive centers in China to determine the location and viability of the embryo. Individual maternal factors, such as a high maternal age (MA) and abnormal ultrasound parameters such as em...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
A 39-year old gravida 8 para 1 (G8P1) woman was admitted to our tertiary gynecology unit with left pelvic pain, a static beta-human chorionic gonadotropin (beta-hCG), and an ultrasound suspicious for left tubal ectopic pregnancy.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Images in Gynecologic Surgery Source Type: research
CONCLUSION: We confirm the high accuracy of TVS diagnosis of ECP relying on five clearly different MTs, independent of its location. The blob and bagel sign emerged as important types (75 % of all ECPs). Histology from CUR was needed when ECP could not be visualized in LSC. Assessment of free fluid was essential and accurate in predicting free blood.PMID:33957680 | DOI:10.1055/a-1487-5030
Source: Ultraschall in der Medizin - Category: Radiology Authors: Source Type: research
Abstract Ovarian vein thrombosis (OVT) is a rare type of venous thromboembolism. The most common risk factors for OVT include pregnancy, oral contraceptives, malignancies, recent surgery, and pelvic infections; however, in 4 to 16% of cases, it can be classified as idiopathic. Most of the available information regards pregnancy-related OVT, which has been reported to complicate 0.01 to 0.18% of pregnancies and to peak around 2 to 6 days after delivery or miscarriage/abortion. The right ovarian vein is more frequently involved (70-80% of cases). Clinical features of OVT include abdominal pain and tenderness, fever,...
Source: Hamostaseologie - Category: Hematology Authors: Tags: Hamostaseologie Source Type: research
CONCLUSIONS: Our study showed that the finding of an amniotic sac without a live embryo on ultrasound ('amniotic sac sign') is a reliable marker of early pregnancy failure and could reduce the number of follow-up scans by 11% in cases of diagnostic uncertainty. This article is protected by copyright. All rights reserved. PMID: 33147646 [PubMed - as supplied by publisher]
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
CONCLUSIONS: Compared to diagnostic laparoscopy only, it is uncertain whether laparoscopic surgery reduces overall pain associated with minimal to severe endometriosis. No data were reported on live birth. There is moderate quality evidence that laparoscopic surgery increases viable intrauterine pregnancy rates confirmed by ultrasound compared to diagnostic laparoscopy only. No studies were found that looked at live birth for any of the comparisons. Further research is needed considering the management of different subtypes of endometriosis and comparing laparoscopic interventions with lifestyle and medical interventions. ...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
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