P –758 The efficacy, safety and proven security of microSecure vitrification offers “peace of mind” and reliability during a global pandemic

AbstractStudy questionUnder deadly pandemic conditions involving the novel SARS-CoV –2 corona virus, could biopsied blastocysts be safely cryopreserved, stored and utilized for subsequent warming cycles?Summary answerBlastocysts were securely stored, effectively warmed and safely transferred to yield normal pregnancy outcomes under uncertain laboratory conditions subject to unprecedented policy changes.What is known alreadyBy April 2020, every IVF lab worldwide was implementing deep cleaning/disinfecting procedures in their laboratory and patient-contact areas, thorough hand-washing policies and mandatory PPE to reduce the chance of contact transmission and spread of the potentially deadly SARS-CoV –2 coronavirus. Furthermore, we know that safeguards like oil overlay culture dishes and pipetting dilution factors provide insurance against possible contamination. However, knowing that the trophectoderm of blastocysts possessed the ACE–2 binding receptor, potential concern existed regarding t he continuation of laser zona opening and biopsy procedures that could possibly expose cryopreserved embryos to the coronavirus in liquid nitrogen storage (vapor or liquid).Study design, size, durationBetween March 8 and December 22, 2020, 508 patients performed FET cycles involving the use of single (n  = 490) or dual (n = 18) euploid microSecure vitrified blastocysts. In this retrospective analysis, we compared clinical pregnancy outcomes to a...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research

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Deaths among people who have been fully vaccinated remain rare, but older adults and those with compromised immune systems are at much higher risk.
Source: NYT Health - Category: Consumer Health News Authors: Tags: your-feed-science Disease Rates Coronavirus (2019-nCoV) Vaccination and Immunization Cancer Multiple Myeloma Immune System Antibodies Multiple Myeloma Research Foundation Powell, Colin L your-feed-health Source Type: news
The CDC released data on Thursday showing that unvaccinated Americans are 11 times as likely to die of COVID-19 than vaccinated people, and six times as likely to be infected.
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A clinical trial from the NIH found that there was no difference in the time of recovery when hospitalized Covid patients were given interferon beta-1a compared to just remdesivir.
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Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. The virus primarily affects the lungs where it induces respiratory distress syndrome ranging from mild to acute, however, there is a growing body of evidence supporting its negative effects on other system organs that also carry the ACE2 receptor, such as the placenta. The majority of newborns delivered from SARS-CoV-2 positive mothers test negative following delivery, suggesting that there are protective mechanisms within the placenta. There appears to be a higher incidence of pregna...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionsThere is an increased risk of abortion in mothers with a positive test result of SARS-CoV-2, which several case reports and case series have identified during the pandemic. Placental inflammation during the viral infection may result in fetal growth retardation and induce abortion. There has not been any consistent evidence of vertical transmission of the virus from mother to fetus, which requires further investigation.
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
Rather a gap since the last one.  Apologies for that.First two things relating to COVID.  The Nuffield Trust have investigatedadverse outcomes for babies born during the pandemic.  And ascoping review about vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2.And other research.  A systematic review of the maternal, fetal, and child outcomes of mental health treatments in women, from the Agency for Healthcare Research and Quality in the USA.  ARCT of delivery mode after manual rotation of occiput posterior fetal positions. Two Cochrane reviews: ...
Source: Browsing - Category: Databases & Libraries Tags: midwifery Source Type: blogs
Abstract SARS-CoV-2 virus was first identified in the beginning of 2020 and has spread all over the world, causing the Coronavirus Disease 2019 (COVID-19) pandemic. The virus is a member of the Coronavirus family, which includes viruses that cause common cold, Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). MERS and SARS are known by causing adverse events in pregnancy. Considering that SARS-CoV-2 is a new infection agent, little is known about the risk of its infection to human embryo/fetal development. However, SARS and MERS were associated with negative outcomes, such as miscarriage...
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research
More than 130 million women give birth around the world each year. During pregnancy, changes in the immune system make women generally more susceptible to respiratory infections. And this year, pregnant women also have to worry about COVID-19, a virus that can affect a person’s lungs and airways. The U.K. government announced on Monday that pregnant women were at an increased risk of severe illness from coronavirus (COVID-19). Speaking at a press conference, Public Health England chief medical officer Chris Whitty said people in the “high risk” category should stay at home for 12 weeks. (That includes pe...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Explainer Londontime Source Type: news
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