P –765 Embryo donation pregnancies are at high risk even in young recipients

AbstractStudy questionAre pregnancies after embryo donation (ED) at higher risk of complications than those issued from autologous frozen-thawed embryo transfer (FET)?Summary answerEven in young women, the risk of pregnancy induced hypertension (PIH) is four time higher in pregnancies after ED versus controls.What is known alreadyAfter oocyte donation, a higher risk of PIH is well described. It is more controversial after sperm donation. The risk origin remains uncertain, even though an immunological explanation seems most likely. In ED, the fetus being fully allogeneic to his parents may be less well-tolerated. Very few data are reported about pregnancies after ED. The same allogenic model exists in surrogacies, but pregnancy complications are not well described in the literature.Study design, size, durationThis anonymous, multicenter, comparative observational retrospective cohort study included all singleton ED pregnancies diagnosed at 7 –8 weeks, from January 2003 to December 2018, in six French ART centers. For each, two controls were matched among autologous FET pregnancies. 209 pregnancies were included: 73 ED and 136 controls. Multiple pregnancies were excluded because of their increased associated obstetrical risks.Participants/materials, setting, methodsControls were matched according to pregnancy date, parity and women ’s age. The first two singleton pregnancies after each index case meeting the selection criteria were retained. Each center coordinator collecte...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research