P –393 The relationship of cigarette smoking with gestational diabetes. An evaluation of a database of more than nine million deliveries

AbstractStudy questionGiven the common pathophysiology between type 2  DM (risk of which is increased by smoking) and GDM we sought to assess whether an association between smoking and GDM exists?Summary answerAfter controlling for confounding effects, women who smoke during pregnancy are at an increased risk of developing GDM.What is known alreadySmoking is well associated with type 2 diabetes mellitus (DM) in multiple studies. It has remained unclear whether there is also an association between smoking and GDM as publications report conflicting results. In a meta-analysis of 1,364,468 pregnancies (22,811 smokers) there was no association between cigarette smoking and the risk of GDM. While a study from the Pregnancy Risk Assessment Monitoring System, on 222,408 patients (54,114 smoked during pregnancy) found a higher risk for GDM among smokers.Study design, size, durationA retrospective population-based study utilizing data from the Healthcare Cost and Utilization Project —Nationwide Inpatient Sample (HCUP-NIS). A dataset of all deliveries between 2004 and 2014 inclusively, was created. Within this group, all deliveries to women who smoked during pregnancy were identified as part of the study group (n = 443,590), and the remaining deliveries were categorized as non smoker births and comprised the reference group (n = 8,653,198).Participants/materials, setting, methodsThe HCUP-NIS is the largest inpatient sample database in the USA, and it is comprised of hospita...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research