P –571 Preimplantation Genetic Testing for Aneuploidies (PGT-A) and pregnancy outcome

AbstractStudy questionFrozen embryo transfer (FET) of euploid blastocysts in hormone replacement therapy (HRT) or natural cycle (NC): are there differences in obstetric, fetal and neonatal outcomes?Summary answerPregnancy complications, neonatal outcomes and fetal abnormalities are not increased after FET with PGT-A in singleton pregnancies.What is known alreadySince its introduction, PGT has been widely used in ART centers for preventing chromosomal and monogenic diseases. Despite its increased use, there are scarce and conflicting data about adverse pregnancy, fetal and neonatal outcomes. In one published study, the risk of preeclampsia and placenta previa was increased when PGT pregnancies were compared with non-PGT, while the incidence of gestational diabetes mellitus (GDM), preterm delivery, fetal defects and NICU (Neonatal Intensive Care Unit) admission were similar. According to other data, the rate of caesarean section in PGT pregnancies was high - around 80% in singletons.Study design, size, durationAn observational, retrospective study was conducted between March 2015 and November 2019 in patients with singleton pregnancies after ART with PGT-A/FET/HRT and NC.A total number of 353 patients from two fertility centers (ART Fertility Clinics Dubai and Abu Dhabi, UAE), were included. They were divided into two groups according to the endometrial preparation for FET: group A: HRT (n ā€‰=ā€‰225) and group B: NC (nā€‰=ā€‰128).Participants/materials, setting, methodsPatient...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research