Preclinical risk evaluation of normal tissue injury with novel radiosensitizers

Genotoxic damage induced by radiation triggers a highly coordinated DNA damage response (DDR), and molecular inhibitors of key nodes within this complex response network can provide profound enhancement in the anti-tumor efficacy of radiation. This is especially true for drugs targeting the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs), which is a core component of the non-homologous end-joining (NHEJ) DNA repair pathway, and Ataxia Telangiectasia mutated (ATM), which coordinates cell cycle arrest, apoptosis and DNA repair functionalities after radiation exposure.

Source: International Journal of Radiation Oncology * Biology * Physics - August 13, 2021 Category: Radiology Authors: Sonja Dragojevic, Ji Jianxiong, Pankaj K. Singh, Margaret A. Connors, Robert W. Mutter, Scott C. Lester, Surabhi M. Talele, Wenjuan Zhang, Brett L. Carlson, Nicholas B. Remmes, Sean S. Park, William F. Elmquist, Sunil Krishnan, Erik J. Tryggestad, Jann N. Source Type: research