Cluster analysis of a large dataset of patients with Lennox-Gastaut syndrome

Lennox-Gastaut syndrome (LGS) is a childhood epilepsy syndrome characterized by multiple seizure types (e.g., tonic, atonic, absences, etc.), a specific interictal electroencephalographic (EEG) pattern [i.e., generalized slow spike-waves (SSW) and/or generalized paroxysmal fast activity (GPFA)], and intellectual/psychosocial dysfunction.1-3 Seizures in LGS are often resistant to antiseizure medications (ASMs); reduction in the frequency of the most incapacitating seizures [i.e., Generalized tonic-clonic (GTC), tonic, and atonic] should be the major objective in their management strategy.

Source: Seizure: European Journal of Epilepsy - August 13, 2021 Category: Neurology Authors: Ali A. Asadi-Pooya, Mehdi Bazrafshan, Mohsen Farazdaghi Source Type: research