siRNA silencing of PD-1 ligands on dendritic cell vaccines boosts the expansion of minor histocompatibility antigen-specific CD8 + T cells in NOD/SCID/IL2Rg(null) mice

In conclusion, adoptive transfer of ex vivo primed MiHA-specific CD8+ T cells in combination with PD-L silenced DC vaccination, targeting MiHAs restricted to the hematopoietic system, is an interesting approach to boost GVT immunity in allo-SCT patients and thereby prevent relapse.

http://link.springer.com/10.1007/s00262-015-1668-6

Source: Cancer Immunology, Immunotherapy - February 28, 2015 Category: Cancer & Oncology Source Type: research