AMP deamination is sufficient to replicate an atrophy-like metabolic phenotype in skeletal muscle

Skeletal muscle atrophy, whether caused by chronic disease, acute critical illness, disuse or aging, is characterized by tissue-specific decrease in oxidative capacity and broad alterations in metabolism that contribute to functional decline. However, the underlying mechanisms responsible for these metabolic changes are largely unknown. One of the most highly upregulated genes in atrophic muscle is AMP deaminase 3 (AMPD3: AMP  → IMP+NH3), which controls the content of intracellular adenine nucleotides (AdN; ATP + ADP + AMP).

Source: Metabolism - Clinical and Experimental - August 12, 2021 Category: Biomedical Science Authors: Spencer G. Miller, Paul S. Hafen, Andrew S. Law, Catherine B. Springer, David L. Logsdon, Thomas M. O'Connell, Carol A. Witczak, Jeffrey J. Brault Source Type: research