Associations of the Polymorphisms in ADIPOQ with Circulating Levels of Adiponectin and Lipids: A Meta-Analysis

Horm Metab Res 2021; 53: 541-561 DOI: 10.1055/a-1543-6362The relationships between the rs266729, rs1501299, and rs2241766 polymorphisms in
adiponectin gene (ADIPOQ) and circulating levels of adiponectin and
lipids remain to be clarified. Databases including PubMed and Embase were
searched for eligible studies. The random-effects model was used, and
standardized mean difference (SMD) with 95% confidence interval (CI) was
calculated to estimate the differences in circulating levels of adiponectin and
lipids between the subjects with different genotypes. A total of 12 810, 17 319,
and 21 361 subjects were identified in the analyses for the rs266729, rs1501299,
and rs2241766 polymorphisms, respectively. G allele carriers of the rs266729
polymorphism had lower levels of adiponectin (SMD=–0.28,
95% CI=–0.43 to–0.12) and high-density
lipoprotein cholesterol (HDL-C) (SMD=–0.10, 95%
CI=–0.17 to–0.02) than CC homozygotes; T allele carriers
of the rs1501299 polymorphism had higher levels of adiponectin
(SMD=0.21, 95% CI=0.05 to 0.36) and HDL-C
(SMD=0.09, 95% CI=0.04 to 0.15) and lower levels of
triglycerides (SMD=–0.06, 95% CI=–0.12
to–0.01) than GG homozygotes; G allele carriers of the rs2241766
polymorphism had lower levels of adiponectin (SMD=–0.18,
95% CI=–0.31 to–0.05) an...

Source: Hormone and Metabolic Research - August 12, 2021 Category: Endocrinology Authors: Su, Mi Jia, Aimei He, Yilan Song, Yongyan Tags: Endocrine Care Source Type: research