Issue Information

Front cover:The expression of RAGE (receptor of advanced glycation end products) was increased on cerebral endothelial cells of mice after systemic infection of P. gingivalis (Porphyromonas gingivalis), a key pathogen of periodontal disease. The upregulated RAGE expressions on cerebral endothelial cells may involve in transporting peripheral A β into brain because RAGE is known as a receptor for peripheral Aβ influx.Image Content: Fluorescent image of brain slice stained with RAGE (green), CD31 (red) and Hoechst (blue) in mice after systemic P.gingivalis infection.Read the full article ‘Receptor for advanced glycation end products up-regulation in cerebral endothelial cells mediates cerebrovascular-related amyloid β accumulation after Porphyromonas gingivalisinfection ’ F. Zeng, Y. Liu, W. Huang, H. Qing, T. Kadowaki, H. Kashiwazaki, J. Ni and Z. Wu (J. Neurochem. 2021, vol. 158 (3), pp. 724 –736) on doi:10.1111/jnc.15096
Source: Journal of Neurochemistry - Category: Neuroscience Tags: Issue Information Source Type: research