The role of S100A9 in the interaction between pancreatic ductal adenocarcinoma cells and stromal cells

ConclusionsPSCs stimulated PDAC cells to secrete S100A9, which acts as a chemoattractant to attract circulatory monocytes into cancer microenvironment and induces expression of PD-L1 on macrophages. High expression of S100A9 and PD-L1 was associated with worse overall survival in a cohort of patients with PDAC.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research