Recent Advances in the Use of Lipid-Based Nanoparticles Against Glioblastoma Multiforme

AbstractGlioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults. Although the overall incidence is less than 10 per 100,000 individuals, its poor prognosis and low survival rate make GBM a crucial public health issue. The main challenges for GBM treatment are related to tumor location and its complex and heterogeneous biology. In this sense, a broad range of nanoparticles with different sizes, architectures, and surface properties, have been engineered as brain drug delivery systems. Among them, lipid-based nanoparticles, such as liposomes, have been pointed out as promising materials to deliver antitumoral drugs to the central nervous system and thus, to improve brain drug targeting and therapeutic efficiency. Here, we describe the synthesis and general characteristics of lipid-based nanoparticles, as well as evidence in the past 5  years regarding their potential use to treat GBM.
Source: Archivum Immunologiae et Therapiae Experimentalis - Category: Allergy & Immunology Source Type: research

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ers Rosendal Korshoej Surgery is essential in the treatment of high-grade gliomas (HGG) and gross total resection (GTR) is known to increase the overall survival and progression-free survival. Several studies have shown that fluorescence-guided surgery with 5-aminolevulinic acid (5-ALA) increases GTR considerably compared to white light surgery (65% vs. 36%). In recent years, sodium fluorescein (SF) has become an increasingly popular agent for fluorescence-guided surgery due to numerous utility benefits compared to 5-ALA, including lower cost, non-toxicity, easy administration during surgery and a wide indication range...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Prog Brain Res. 2022;268(1):315-327. doi: 10.1016/bs.pbr.2021.10.039. Epub 2021 Dec 14.ABSTRACTGKNS for uveal melanoma has become a recognized valued treatment which avoids enucleation of the eye. In the early days, the eccentric location of these tumors made treatment difficult, but Gamma Knife Perfexion has solved that problem. It is known that larger tumors and tumors with an anterior location have a worse prognosis. GKNS has also been of rather unexpected benefit in optic nerve gliomas that require treatment. Choroidal hemangiomas may benefit from treatment as can secondary glaucoma. It has also been found to be benefi...
Source: Brain Research - Category: Neurology Authors: Source Type: research
Prog Brain Res. 2022;268(1):271-277. doi: 10.1016/bs.pbr.2021.10.036. Epub 2021 Dec 14.ABSTRACTLow grade gliomas concern grade I and grade II tumors. The only grade one tumor is the pilocytic astrocytoma. This is a well-defined tumor with characteristic histology, often accompanied by a cyst. GKNS has been used in surgically inaccessible tumors since 1994. More recently it has been demonstrated that the tumors are more treatment resistant in adults than in children. Grade II tumors include oligodendrogliomas and grade II diffuse astrocytomas. The standard treatment for oligodendrogliomas us total removal followed by fracti...
Source: Brain Research - Category: Neurology Authors: Source Type: research
Prog Brain Res. 2022;268(1):259-270. doi: 10.1016/bs.pbr.2021.10.035. Epub 2021 Dec 14.ABSTRACTGKNS has a limited role in the management of malignant gliomas. It has little or nothing to offer in primary treatment. However, there is evidence that with recurrent tumors which are 4cm in diameter or less, in younger patients, GKNS used together with bevacizumab can prolong overall survival. Nonetheless, more research is required to determine the precise role of the technique.PMID:35074084 | DOI:10.1016/bs.pbr.2021.10.035
Source: Brain Research - Category: Neurology Authors: Source Type: research
CONCLUSION: CfDNA levels showed good diagnostic discrimination in glioma, GBC, breast, lung carcinoma, and OSCC. Significant increase in titers was evident with increase in cancer stage from I to IV in breast, GBC and OSCC.PMID:35074971 | DOI:10.4103/IJPM.IJPM_474_20
Source: Indian Journal of Pathology and Microbiology - Category: Pathology Authors: Source Type: research
J Leukoc Biol. 2022 Jan 24. doi: 10.1002/JLB.5MA1221-468R. Online ahead of print.ABSTRACTPolypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts), a group of isoenzymes that initiate mucin-type O-glycosylation, have been shown to mediate tumor growth and metastasis in various cancer types. However, data on the clinical significance and features of GalNAc-Ts remain scant. Here, we used Oncomine and The Cancer Genome Atlas (TCGA) databases to analyze the transcription and survival effect of GALNTs (N-acetylgalactosaminyltransferase genes) in pan-cancer. The data showed that the GALNTs were aberrantly expressed in various h...
Source: Journal of Leukocyte Biology - Category: Hematology Authors: Source Type: research
Adv Drug Deliv Rev. 2022 Jan 22:114115. doi: 10.1016/j.addr.2022.114115. Online ahead of print.ABSTRACTCNS tumors remain among the deadliest forms of cancer, resisting conventional and new treatment approaches, with mortality rates staying practically unchanged over the past 30 years. One of the primary hurdles for treating these cancers is delivering drugs to the brain tumor site in therapeutic concentration, evading the blood-brain (tumor) barrier (BBB/BBTB). Supramolecular nanomedicines (NMs) are increasingly demonstrating noteworthy prospects for addressing these challenges utilizing their unique characteristics, such ...
Source: Advanced Drug Delivery Reviews - Category: Drugs & Pharmacology Authors: Source Type: research
Dev Cell. 2022 Jan 24;57(2):260-276.e9. doi: 10.1016/j.devcel.2021.12.020.ABSTRACTMetabolic flexibility is a hallmark of many cancers where mitochondrial respiration is critically involved, but the molecular underpinning of mitochondrial control of cancer metabolic reprogramming is poorly understood. Here, we show that reverse electron transfer (RET) through respiratory chain complex I (RC-I) is particularly active in brain cancer stem cells (CSCs). Although RET generates ROS, NAD+/NADH ratio turns out to be key in mediating RET effect on CSC proliferation, in part through the NAD+-dependent Sirtuin. Mechanistically, Notch...
Source: Developmental Cell - Category: Cytology Authors: Source Type: research
nstra Despite clinical intervention, glioblastoma (GBM) remains the deadliest brain tumor in adults. Its incurability is partly related to the establishment of drug resistance, both to standard and novel treatments. In fact, even though small kinase inhibitors have changed the standard clinical practice for several solid cancers, in GBM, they did not fulfill this promise. Drug resistance is thought to arise from the heterogeneity of GBM, which leads the development of several different mechanisms. A better understanding of the evolution and characteristics of drug resistance is of utmost importance to improve the curre...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Functional MRI (fMRI) demonstrated that experiences of racial discriminatio...Read more on AuntMinnie.comRelated Reading: fMRI shows multiple concussions can affect teen brains fMRI sheds light on how trauma affects the brain fMRI shows how brain organizes memories into a single narrative fMRI finds differences in the brains of obese children Using fMRI to plan brain tumor resection boosts patient outcomes
Source: Headlines - Category: Radiology Source Type: news
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