New Approaches to the Prevention and Treatment of Viral Diseases

AbstractThe review discusses a new approach to the prevention and treatment of viral infections based on the use of pine needles polyprenyl phosphate (PPP) and associated with the infringement of prenylation process —the attachment of farnesol or geranyl geraniol to the viral protein. Currently, prenylation has been detected in type 1 adenovirus, hepatitis C virus, several herpes viruses, influenza virus, HIV. However, this list is far from complete, given that prenylated proteins play an extremely important role in the activity of the virus. We assume that the interferon produced in response to PPP may suppress expression of the SREBP2 transcription factor. As a result, the mevalonic acid pathway is violated and, as a result, the formation of early polyprenols precursors (geraniol, geranyl geraniol, fa rnesol), which are necessary for the prenylation of viral proteins, is blocked and the formation of mature, virulent virus particles is broken. As a consequence, the maturation of viral particles is inhibited, and defective particles are formed. Polyprenol was extracted from greenery (pine, fir and spruce needles, mulberry leaves, etc.), purified by chromatography, phosphorylated and identified by HPLC and NMR. Obtained PPP was used as antiviral in some experimental models in vitro and in vivo. During numerous studies, it was found that PPP manifested versatile antiviral effects, both in vitro and in vivo. The maximum effect was observed with viruses in which the presenc...
Source: Archivum Immunologiae et Therapiae Experimentalis - Category: Allergy & Immunology Source Type: research

Related Links:

This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Mariana Rodriguez-Hakim, Linard R äz, Jan Vermant Some contagious diseases, such as COVID-19, spread through the transmission of aerosols and droplets. Aerosol and droplet formation occurs inside and outside of the respiratory tract, the latter being observed... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Soft Matter latest articles - Category: Chemistry Authors: Source Type: research
Abbott Laboratories has distributed more than 1.4 billion Covid-19 tests globally since the start of the pandemic, including around 300 million in the fourth quarter of 2021. Its global Covid-19 testing-related sales were $2.3 billion in the fourth quarter and $7.7 billion for the full year in 2021.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
A deep molecular dive into COVID-19 patients found that the presence of autoantibodies in peripheral blood at initial diagnosis was the chief of four risk factors predicting if a patient would experience long COVID.Medscape Medical News
Source: Medscape Internal Medicine Headlines - Category: Internal Medicine Tags: Internal Medicine News Source Type: news
NIH-sponsored study assessed dose in adults fully vaccinated with any EUA or approved COVID-19 vaccine
Source: National Institutes of Health (NIH) News Releases - Category: American Health Source Type: news
AbstractPurposesThe spread of coronavirus disease 2019 (COVID-19) has affected socioeconomic and healthcare systems in many countries. Accordingly, many individuals may have canceled their annual health-check programs, including esophagogastroduodenoscopy, which would have resulted in lower numbers of newly diagnosed patients with gastric cancer in comparison to other times.MethodsQuestionnaires were distributed to 62 hospitals every week from May 2020 to August 2020 (total 744) through mailing lists of the Stomach Cancer Study Group of the Japan Clinical Oncology Group. The number of patients with gastric cancer and hospi...
Source: Surgery Today - Category: Surgery Source Type: research
Despite declining national numbers, Americans should not lose sight of the ongoing public health crisis as hospitals remain overwhelmed with COVID-19 patients, many of whom are unvaccinated.WebMD Health News
Source: Medscape Internal Medicine Headlines - Category: Internal Medicine Tags: Infectious Diseases News Source Type: news
The James Webb Space Telescope traveled nearly 1.6 million km (1 million mi.) to reach a destination that, in some ways, is nowhere at all. On Jan. 24, just shy of one month after its Christmas Day launch, the $10 billion observatory arrived at a spot in space known as L2—where the gravity of the sun and the Earth effectively cancel each other out, allowing the spacecraft to circle an invisible point as if it were orbiting a solid body like a planet. There the telescope will station-keep for up to the next 20 years, peering deeper into space than any observatory ever has before. The one-month flight was the culminati...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized healthscienceclimate Source Type: news
My local park has notices up about an outbreak.  Here are sources of latest official information (for the UK).  Travel related information is at the end of the post. In addition to the sites below try your local authority's website.Animal and Plant Health Agency reports relating to wild birdsDEFRA and APHA, preliminary outbreak assessment, for Europe, Russia and the UK - includes Weekly disease reportsDEFRA and APHA, guidanceDepartment of Agriculture, Environment and Rural Affairs (Northern Ireland), Avian influenzaHealth and Safety Executive, Avian influenza(PDF) (information particularly for those in ...
Source: Browsing - Category: Databases & Libraries Tags: avian influenza Source Type: blogs
The COVID-19 pandemic forced many healthcare providers to rely on telehealth technology to provide clinical services to patients unable or unwilling to visit in person.Medscape Reader Polls
Source: Medscape Business of Medicine Headlines - Category: Pharmaceuticals Tags: Family Medicine/Primary Care News Source Type: news
Individuals with moderate to severe depressive symptoms are more likely to say they believe misinformation about COVID-19 vaccines than those without depressive symptoms, according to areport in JAMA Open Network. Moreover, individuals who believed misinformation about COVID vaccines were less likely to be vaccinated or be willing to get the vaccine.“As such, individuals already burdened with depression may be at a higher risk of COVID-19,” wrote lead author Roy H. Perlis, M.D., M.Sc., of Massachusetts General Hospital and colleagues.The researchers analyzed data from U.S. adults who responded to at least one o...
Source: Psychiatr News - Category: Psychiatry Tags: APA election COVID COVID vaccine depression JAMA Network Open misinformation survey U.S. adults Source Type: research
More News: Adenoviruses | Allergy & Immunology | Clinical Trials | Cold Sores | Coronavirus | COVID-19 | Encephalitis | Hepatitis | Hepatitis A | Hepatitis C | Herpes | Influenza | Orthopaedics | Study | Tickborne Diseases