New Approaches to the Prevention and Treatment of Viral Diseases

AbstractThe review discusses a new approach to the prevention and treatment of viral infections based on the use of pine needles polyprenyl phosphate (PPP) and associated with the infringement of prenylation process —the attachment of farnesol or geranyl geraniol to the viral protein. Currently, prenylation has been detected in type 1 adenovirus, hepatitis C virus, several herpes viruses, influenza virus, HIV. However, this list is far from complete, given that prenylated proteins play an extremely important role in the activity of the virus. We assume that the interferon produced in response to PPP may suppress expression of the SREBP2 transcription factor. As a result, the mevalonic acid pathway is violated and, as a result, the formation of early polyprenols precursors (geraniol, geranyl geraniol, fa rnesol), which are necessary for the prenylation of viral proteins, is blocked and the formation of mature, virulent virus particles is broken. As a consequence, the maturation of viral particles is inhibited, and defective particles are formed. Polyprenol was extracted from greenery (pine, fir and spruce needles, mulberry leaves, etc.), purified by chromatography, phosphorylated and identified by HPLC and NMR. Obtained PPP was used as antiviral in some experimental models in vitro and in vivo. During numerous studies, it was found that PPP manifested versatile antiviral effects, both in vitro and in vivo. The maximum effect was observed with viruses in which the presenc...
Source: Archivum Immunologiae et Therapiae Experimentalis - Category: Allergy & Immunology Source Type: research

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This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Mariana Rodriguez-Hakim, Linard R äz, Jan Vermant Some contagious diseases, such as COVID-19, spread through the transmission of aerosols and droplets. Aerosol and droplet formation occurs inside and outside of the respiratory tract, the latter being observed... The content of this RSS Feed (c) The Royal Society of Chemistry
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Abbott Laboratories has distributed more than 1.4 billion Covid-19 tests globally since the start of the pandemic, including around 300 million in the fourth quarter of 2021. Its global Covid-19 testing-related sales were $2.3 billion in the fourth quarter and $7.7 billion for the full year in 2021.
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My local park has notices up about an outbreak.  Here are sources of latest official information (for the UK).  Travel related information is at the end of the post. In addition to the sites below try your local authority's website.Animal and Plant Health Agency reports relating to wild birdsDEFRA and APHA, preliminary outbreak assessment, for Europe, Russia and the UK - includes Weekly disease reportsDEFRA and APHA, guidanceDepartment of Agriculture, Environment and Rural Affairs (Northern Ireland), Avian influenzaHealth and Safety Executive, Avian influenza(PDF) (information particularly for those in ...
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