Gut Microbiota Diversity in HIV-Infected Patients on Successful Antiretroviral Treatment is Linked to Sexual Preferences but not CD4 Nadir
AbstractThe effects of HIV infection and antiretroviral therapy (ART) on the gut microbiome are poorly understood and the literature data are inconsistent. The aim of this study was to assess the alpha and beta diversity of the fecal microbiota in HIV-infected patients on successful antiretroviral therapy with regard to sexual preferences and CD4 nadir. Thirty-six HIV-infected ART-treated patients with HIV viremia below 20 copies/ml and CD4 > 500 cells/μl were divided into two subgroups based on CD4 nadir. The composition of the intestinal microbiota was assessed by 16SrRNA sequencing (MiSeq Illumina). The alpha and beta diversity were analyzed according to CD4 nadir count and sexual preference. Several alpha diversity indexes were s ignificantly higher in the MSM group than in heterosexual patients. The alpha diversity did not differ significantly between patients with CD4 nadir> 500 cells/μl and CD4 nadir
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In the article “New treatments for chronic urticaria” by P Kolkhir et al (Ann Allergy Asthma Immunl 2020:124(1): 2-12), the following text has been removed. The article has been corrected online at https://doi.org/10.1016/j.anai.2019.08.014.
Technology is one of those items with which all clinicians (probably everyone) seem to have a love-hate relationship. The electronic medical record has made documenting and billing patient encounters much easier, yet at the same time, it seems to have erected a barrier between the patient and provider. Along with the growth of the electronic health record has been an explosion in the use of handheld devices and health-related applications (apps). These apps allow for more engagement and involvement with patients, including health monitoring by providers.
We thank the respondents to our article1 for their insightful comments. Although we have matched subjects in both cohorts by age, sex, comorbidities, and index date, Lin et al2 indicate a lack of adjustment for co-medication status, including the use of corticosteroids and disease-modifying antirheumatic drugs (DMARDs), in the propensity score. We agree that these medications are important confounders on fracture. We therefore had conducted multivariate analysis in t he published article by adjustment for corticosteroids, DMARDs, and phototherapy.
We read with great interest the article by Lin et al1 reporting the association of incidental fractures in patients with atopic dermatitis (AD). We appreciate the authors who collected data from Taiwan's National Health Insurance Research Database and conducted a great cohort study. Nevertheless, we highlight some key points.