Cancers, Vol. 13, Pages 3980: miRNAs as Biomarkers for Diagnosing and Predicting Survival of Head and Neck Squamous Cell Carcinoma Patients

Cancers, Vol. 13, Pages 3980: miRNAs as Biomarkers for Diagnosing and Predicting Survival of Head and Neck Squamous Cell Carcinoma Patients Cancers doi: 10.3390/cancers13163980 Authors: Igor Piotrowski Xiang Zhu Tatiana Dandolini Saccon Sarah Ashiqueali Augusto Schneider Allancer Divino de Carvalho Nunes Sarah Noureddine Agnieszka Sobecka Wojciech Barczak Mateusz Szewczyk Wojciech Golusiński Michal M. Masternak Paweł Golusiński Head and Neck Squamous Cell Carcinoma (HNSCC) is the sixth most common cancer worldwide. These tumors originate from epithelial cells of the upper aerodigestive tract. HNSCC tumors in different regions can have significantly different molecular characteristics. While many microRNAs (miRNAs) have been found to be involved in the regulation of the carcinogenesis and pathogenesis of HNSCC, new HNSCC related miRNAs are still being discovered. The aim of this study was to explore potential miRNA biomarkers that can be used to diagnose HNSCC and prognose survival of HNSCC patients. For this purpose, we chose a panel of 12 miRNAs: miR-146a-5p, miR-449a, miR-126-5p, miR-34a-5p, miR-34b-5p, miR-34c-5p, miR-217-5p, miR-378c, miR-6510-3p, miR-96-5p, miR-149-5p, and miR-133a-5p. Expression of these miRNAs was measured in tumor tissue and neighboring healthy tissue collected from patients diagnosed with HNSCC (n = 79) in either the oral cavity, oropharynx, or larynx. We observed a pattern of differentially expressed miRNAs at each...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research