Biochemical, pathological and ultrastructural investigation of whether lamotrigine has neuroprotective efficacy against spinal cord ischemia reperfusion injury

During the thoracoabdominal aortic surgery, cessation and restoring of spinal cord blood flow can cause initially ischemic and subsequently reperfusion injury on the neuronal structures which is called the ischemia/reperfusion injury of spinal cord (SCIRI) (1). Paraplegia as a result from SCIRI results in physically, socially and financially deprived victims (2). SCIRI is a composite of interwoven pathological pathways result in apoptotic cell death which includes decreases of cellular energy production, mitochondrial dysfunction, alteration of ionic distribution, loss of membrane potential, depolarization of cellular membranes, extreme discharge of glutamate, alterations of glutamate receptor activations and glutamate transporter expression, increase in oxidative stress and inflammation (3,4).
Source: Injury - Category: Orthopaedics Authors: Source Type: research