Anti ‐GM2 antibodies associated meningoradiculitis in the context of HIV immune reconstitution inflammatory syndrome

AbstractA 71 year-old patient diagnosed with HIV-1 infection developed neurological symptoms congruent with meningoradiculitis one month after initiation of antiretroviral therapy (ART). Concurrent syphilitic seroconversion raised the hypothesis of neurosyphilis, which was later infirmed. Serum antiganglioside IgM antibodies were highly positive. Previous studies have demonstrated that GM2 is overexpressed on HIV-1 infected T lymphocytes. Treatment with intravenous immunoglobulins was effective. We postulate that meningoradiculitis in this patient was a consequence of anti-GM2 antibodies produced as part of an anti HIV-1 immune response. This phenomenon falls within the scope of auto-immune manifestations linked to immune reconstitution inflammatory syndrome.

Source: Clinical and Experimental Neuroimmunology - August 5, 2021 Category: Neurology Authors: N Forgeard, E Januel, A Blancher, L Fonquernie, A Gautheret ‐Dejean, J Neil, M‐C Meyohas Tags: CASE REPORT Source Type: research