Effects of Sevelamer Carbonate on Advanced Glycation End Products and Antioxidant/Pro-Oxidant Status in Patients with Diabetic Kidney Disease.

CONCLUSIONS: SC reduced circulating and cellular AGEs, increased antioxidants, and decreased pro-oxidants, but did not change HbA1c or the albumin/creatinine ratio overall in patients with T2DM and DKD. Because subanalyses revealed that SC may reduce HbA1c and albuminuria in some patients with T2DM with DKD, further studies may be warranted.
PMID: 25710801 [PubMed - as supplied by publisher]

Source: Clinical Journal of the American Society of Nephrology : CJASN - February 20, 2015 Category: Urology & Nephrology Authors: Yubero-Serrano EM, Woodward M, Poretsky L, Vlassara H, Striker GE, on behalf of AGE-less Study Group Tags: Clin J Am Soc Nephrol Source Type: research