When Old Becomes New —Repurposing Cytotoxic Chemotherapy With Radiation to Improve Outcomes in Women With Aggressive Forms of Breast Cancer

Breast cancer locoregional recurrence rates have decreased in recent years due to advances in the multidisciplinary management of the disease, most notably improvements in systemic therapy. Thus, investigating treatment de-escalation strategies in favorable subsets has been a prominent focus of recent trials. In contrast, outcomes remain unsatisfactory in some subtypes despite aggressive chemotherapy, surgery, and radiation therapy. Triple negative breast cancer (TNBC) lacks expression of the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 gene and is characterized by higher rates of relapse and death compared with other subsets of the disease.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Editorial Source Type: research