Proadrenomedullin and neonatal sepsis: a systematic review and meta-analysis of diagnostic accuracy

Conclusion: The findings of our meta-analysis suggest that proadrenomedullin is elevated in neonates with sepsis. However, future prospective cohort studies need to be conducted in order to assess its diagnostic accuracy.What is Known:• Proadrenomedullin has been found increased in adult patients with infectious diseases such as community acquired pneumonia.• Proadrenomedullin plays a major role in the pathophysiology of sepsis in adults.What is New:• Proadrenomedullin is increased in neonates with sepsis.• Future cohort studies need to be conducted in order to elucidate the value of proadrenomedullin in a safer way.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research