Amelanotic melanocytoma of the cervicomedullary junction

Clin Neuropathol. 2021 Aug 2. doi: 10.5414/NP301411. Online ahead of print.ABSTRACTA 64-year-old female with a 1-year history of gait difficulties and right-sided dysesthesias was found to have an intra-axial left-sided exophytic cervicomedullary enhancing mass. Microscopic, immunohistochemical, and ultrastructural findings demonstrated an amelanotic melanocytic neoplasm. Next-generation sequencing with a targeted exomic oncopanel identified a variant of functional significance in the GNA11 gene, thus confirming the diagnosis of a primary amelanotic melanocytoma. The crucial distinction from a melanoma was possible by correlating all of these studies that utilize different technologies.PMID:34338195 | DOI:10.5414/NP301411
Source: Clinical Neuropathology - Category: Pathology Authors: Source Type: research