Chemotherapy-induced peripheral neuropathy is promoted by enhanced spinal insulin-like growth factor-1 levels via astrocyte-dependent mechanisms

CONCLUSION: Our results indicate a vital role for IGF-1 signaling in CIPN. Targeting IGF-1 signaling could be a potent therapeutic strategy for treating CIPN in clinical settings.PMID:34333050 | DOI:10.1016/j.brainresbull.2021.07.026

Source: Brain Research - August 1, 2021 Category: Neurology Authors: Yue Le Xin Chen Long Wang Wan-You He Jian He Qing-Ming Xiong Yun-Hua Wang Lei Zhang Xue-Qin Zheng Han-Bing Wang Source Type: research