RNA modifications in skin cancer focus of Keystone Lecture

In NIEHS-sponsored talk, Yu-Ying He, Ph.D., suggested RNA modifications are crucial players in regulating gene-environment interactions. (read more)
Source: Environmental Factor - NIEHS Newsletter - Category: Environmental Health Source Type: news

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Cancer Immunol Res. 2021 Sep 24:canimm.0094.2021. doi: 10.1158/2326-6066.CIR-21-0094. Online ahead of print.ABSTRACTDendritic cells (DCs), the classical antigen-presenting cells of the immune system, switch from an adhesive, phagocytic phenotype in tissues, to a mature, non-adhesive phenotype that enables migration to lymph nodes to activate T cells and initiate antitumor responses. Monocyte-derived DCs are used in cancer immunotherapy but their clinical efficacy is limited. Here, we show that cultured bone marrow-derived DCs (BM-DCs) expressing dysfunctional β2-integrin adhesion receptors displayed enhanced tumor rej...
Source: Cell Research - Category: Cytology Authors: Source Type: research
J Immunol. 2021 Sep 24:ji2001261. doi: 10.4049/jimmunol.2001261. Online ahead of print.ABSTRACTSystemic suppression of adaptive immune responses is a major way in which UV radiation contributes to skin cancer development. Immune suppression is also likely to explain how UV protects from some autoimmune diseases, such as multiple sclerosis. However, the mechanisms underlying UV-mediated systemic immune suppression are not well understood. Exposure of C57BL/6 mice to doses of UV known to suppress systemic autoimmunity led to the accumulation of cells within the skin-draining lymph nodes and away from non-skin-draining lymph ...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Source Type: research
The National Cancer Institute (NCI) awarded Penn Medicine and The Wistar Institute $11.7 million to support melanoma research. The five-year award from the NCI's Specialized Programs of Research Excellence will be used to fund three new melanoma research projects. The projects will seek to translate laboratory discoveries made in the Perelman School of Medicine at the University of Pennsylvania and at The Wistar Institu te, both in West Philadelphia, into new therapeutics to treat skins cancers. Melanoma…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
This article reviews the abnormal expression of miR-802 in a variety of tumors, expounds the mechanism by which miR-802 affects tumor progression by regulating different target genes, and elaborates the network of miR-802-related ceRNAs. We also summarized the limitations of miR-802 research and looked forward to the potential application of miR-802 in the diagnosis and prognosis of tumors.PMID:34558723 | DOI:10.1002/jcla.23989
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
Pharmacol Res. 2021 Sep 21:105911. doi: 10.1016/j.phrs.2021.105911. Online ahead of print.ABSTRACTIn melanomas, therapy resistance can arise due to a combination of genetic, epigenetic and phenotypic mechanisms. Due to its crucial role in DNA supercoil relaxation, TOP1 is often considered an essential chemotherapeutic target in cancer. However, how TOP1 expression and activity might differ in therapy sensitive versus resistant cell types is unknown. Here we show that TOP1 expression is increased in metastatic melanoma and correlates with an invasive gene expression signature. More specifically, TOP1 expression is highest i...
Source: Cell Research - Category: Cytology Authors: Source Type: research
This article reviews the abnormal expression of miR-802 in a variety of tumors, expounds the mechanism by which miR-802 affects tumor progression by regulating different target genes, and elaborates the network of miR-802-related ceRNAs. We also summarized the limitations of miR-802 research and looked forward to the potential application of miR-802 in the diagnosis and prognosis of tumors.PMID:34558723 | DOI:10.1002/jcla.23989
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Source Type: research
We thank Dr. Tomoyuki Kawada for his comments on the clinicopathologic variables and gene expression profile (CP-GEP) model for melanoma risk stratification [1]. CP-GEP combines clinicopathologic (CP) variables and a gene expression profile (GEP) to identify primary cutaneous melanoma at high risk of metastasis [2,3]. We appreciate Dr. Kawada's remarks on the prognostic value of CP variables and concur that research on melanoma risk-stratification must continue.
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Letter to the Editor Source Type: research
co García-Río David Gozal Obstructive sleep apnea (OSA) is associated with increased cutaneous melanoma incidence and adverse outcomes. Exosomes are secreted by most cells, and play a role in OSA-associated tumor progression and metastasis. We aimed to study the effects of plasma exosomes from OSA patients before and after adherent treatment with continuous positive airway pressure (CPAP) on melanoma cells lines, and also to identify exosomal miRNAs from melanoma cells exposed to intermittent hypoxia (IH) or normoxia. Plasma-derived exosomes were isolated from moderate-to-severe OSA patients before (V1)...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
J Chad Brenner As immunotherapies targeting the PDL1 checkpoint have become a mainstay of treatment for a subset of head and neck squamous cell carcinoma (HNSCC) patients, a detailed understanding of the mechanisms underlying PDL1-mediated immune evasion is needed. To elucidate factors regulating expression of PDL1 in HNSCC cells, a genome-wide CRISPR profiling approach was implemented to identify genes and pathways conferring altered PDL1 expression in an HNSCC cell line model. Our screen nominated several candidate PDL1 drivers, including Toll-like Receptor 2 (TLR2). Depletion of TLR2 blocks interferon-γ-ind...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
ConclusionsA radiological label was successfully established to predict the LRFS of oesophageal squamous cell carcinoma after radiotherapy. The radiomics nomogram was complementary to the clinical prognostic features and could improve the prediction of the LRFS after radiotherapy for oesophageal cancer.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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