Exosomal DNMT1 mRNA Transcript is Elevated in Acute Lymphoblastic Leukemia which might Reprograms Leukemia Progression

DNMT1 is an enzyme which catalyzes and transfers methyl groups to specific CpG fragments in DNA, and this process is defined as DNA methylation, DNMT1 was cloned by DNMT1 gene [1]. The major responsibility of DNMT1 is maintenance of DNA methylation and regulation of epigenetics [2]. Epigenetic factors (DNA methylation, gene regulation, and chromatin remodeling) contribute to predominant role in acute lymphoblastic leukemia (ALL) development and progression [3-5]. Dysregulated expression of DNMT1 causes aberrant DNA methylation which ultimately leads to tumors and abnormalities in normal developmental process [6, 7].
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research